nursing-nutraceuticals-2018-scientifictracks

Page 33

Notes:

allied

academies

Nov 12-13, 2018 | Paris, France

Nutraceuticals and Food Sciences

International Conference on

Nursing and Healthcare

Joint Event

Journal of Food science and Nutrition | Volume 1

Dacrabazine loaded nano structure formulation for the effective treatment of Melanoma

Abdul Hafeez

Glocal Pharmacy School, India

elanoma is one of the type of cancer of skin which

generates from the pigment cells known as melanocytes

of skin and covers global economic burden for the treatment.

Regular exposure of skin of genetically susceptible person to ulta

violet radiationrange is themaincauseof inductionofmelanoma

in skin. Dacarbazine which is chemically imidazolecarboxamide

is utilized as a drug of choice for the treatment of melanoma

as well as Hodgkin’s lymphoma cancer. Dacarbazine induces

programmed cell death (apoptosis) in the cancerous cells of

melanoma by inhibition of synthesis of DNA. Major drawback

with this drug is its poor solubility in water, short shelf life in

systemic circulation, low rate of response and severe adverse

effect which limit its utility. I this study dacarbazine in the form

of nanoformuation (size >100nm) was utilized for augmenting

the anticancer effect of chemotherapeutic drug. In current study

Dacarbazine nanostructured lipid particles (DTIC-NLPs) were

prepared by solvent diffusion method. In drug release study

the drug shows depressed release in free form in comparison

to DTIC-NLPs after 48 hrs in PBS (pH 7.4). MTT assay showed

its strong cytotoxic potential as compare to simple dacarbazine

suspension.

Speaker Biography

Abdul Hafeez has completed his M Pharm in Pharmaceutics from Teerthankar

Mahaveer University, Moradabad and pursuing doctoral studies from Glocal University,

Saharanpur Uttar Pradesh India in Pharmaceutics department, Glocal School of

Pharmacy, a premier rising university. He has published more than 10 papers in reputed

journals and has been serving as an editorial board member of repute. He attended

many national and internationals conferences. Recently he has given oral presentation

in Asia Pharma Conference in Kuala Lumpur, Malaysia in July 2016. He is a member of

reputed pharmaceutical societies like Association of Pharmaceutical Teachers of India

(APTI) and Indian Pharmacy Graduate Association (IPGA).