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academies
Volume 2
June 11-13, 2018 | London, UK
Neurology and Neuroscience
6
th
International Conference on
Mechanism of action of roller technique after damage with Notexine in rats.
Carlos Colmena, Adrian Jorda, Sol Guerra-Ojeda, Constanza Aldasoro, Patricia Marchio, M Dolores Mauricio, Martin Aldasoro, Antonio
Iradi, Jose M Vila
and
Soraya L. Valles
University of Valencia, Spain
T
his study aims to elucidate the interplay among
neuroinflammation, neuronal death and mitochondrial
dysfunction in rats after notexine and roller action added to
muscle in rats. Rats from 7 mounts were treated with notexine
(a toxin that destroy muscle and neural cells) and/or roller
technique. Roller technique is used in humans to recover
from muscle damage and destruction of communication
between neurons and muscle. Also, we tried to ascertain how
the factor above mentioned influences the progression of
neurodegeneration from muscle nervous system to the brain.
This aimwas pursuedby evaluating, by immnunohistochemistry
and/or Western blotting, the neurochemical changes featuring
neurodegeneration in different muscle of the body and
brain regions. Specially, we evaluated MAP-2 and amyloid-β
as markers of neurodegeneration and cellular dysfunction.
Moreover, our results detected increase in pro-inflammatory
proteins in notexine group compared to control or roller group
withadecrease inpro-inflammatoryproteins innotexine+ roller
group. Furthermore, we detected an increase in PPAR-γ (anti-
inflammatory protein) in notexine + roller group compared to
notexine group. Finally, using immunohistochemistry we detect
changes in muscle structure with affectation in notexine group,
with a recovery situation in notexine + roller group in our model
of rats. In summary, roller action in muscle after damage may
producebenefits, suchas increase inanti-inflammatoryproteins
and reduction of pro-inflammatory proteins, conducted to
a higher recovery of both muscle and neurons damages.
Speaker Biography
Carlos Colmena born in Valencia and finished his Degree in 2010 in Physiotherapy
Faculty of Valencia, Spain. He has obtained 3 Masters with the title: 1- Attention
of Physiotherapy community. 2- Prevention in workers inside physiotherapy.
3- New rolls in Health and Physiotherapy. In 2017 has started his PhD in the
Department of Physiology, University of Valencia with Dr. Soraya L. Valles. The
title of his PhD will be “Función protectora y de recuperación de la electrolisis
percutánea intratisular como técnica fisioterápica en tendón rotuliano de rata”.
e:
carcarmafisio@gmail.com