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Page 72
allied
academies
Volume 2
June 11-13, 2018 | London, UK
Neurology and Neuroscience
6
th
International Conference on
Imaging of Tau in the Retina
Umur Kayabasi
Uskudar University, Turkey
Introduction:
Tau protein plays a crucial role in many
neurodegenerative diseases including Alzheimer’s disease
(AD). Tau inclusions and amyloid beta (AB) depositions have
been described in the post-mortem retina exams of AD
patients. Cryo- electron microscopy (Cryo- EM) was recently
used to detect the detailed structure of Tau filaments.
Methods and Result:
We examined the retinas of PET-proven
liveADpatientsbyspectral domainoptical scanning tomography
(SD- OCT) and fundus auto fluoresce in (FAF). The hyper or
hypo- fluorescent lesions in the retinawere scanned byOCT and
imagesthatcompletelycorrespondedwiththehistopathological
and Cryo- EM shapes of Tau filaments were observed.
Conclusion:
Retinal Tau is a very promising target to detect
early changes in AD and retinal imaging may be an exciting
and trustable technique to predict and monitor the disease.
e:
kayabasi@yahoo.com