neuroscience-2018-posters-abstracts

Page 71

allied

academies

Volume 2

June 11-13, 2018 | London, UK

Neurology and Neuroscience

International Conference on

Serotonin-1A receptor expression in the reinforcing effects of methylphenidate

Tabinda Salman, Shazia Nawaz, Rizwana S Waraich

and

Darakhshan J Haleem

University of Karachi, Pakistan

ethylphenidate(MPD) is widely prescribed for

the treatment of attention deficit hyperactivity

disorder(ADHD). Despite its therapeutic importance,

there is growing evidence that patients treated with MPD

develop an addiction to their therapy. It is therefore

important to monitor abuse potential and understanding

molecular mechanism involved in cognition enhancing and

reinforcing effects of MPD. This experiment is designed to

study abuse potential, if any, of clinically relevant doses

of MPD. In view of a role of 5-HT(serotonin)1A receptor in

cognition as well as addiction, the expression of 5-HT-1A

receptors in the prefrontal cortex and nucleus accumbens

is monitored in rats repeatedly treated with MPD. We

found that lower and clinically relevant doses (0.5 and 2.5

mg/kg) of MPD enhanced learning acquisition and memory

retention in a dose dependent manner, but higher doses (5

mg/kg) impaired these. The drug administered repeatedly

at a dose of 2.5 mg/kg produced only mild and transient

sensitization but was reinforcing. Repeated MPD treated

animals exhibited improved memory retention but no

effect occurred on learning acquisition. The expression of

5-HT-1A receptor was markedly attenuated in the nucleus

accumbens, but not in the prefrontal cortex. The results

supporting a role of 5-HT-1A receptors in addiction are of

use in improving therapeutics in ADHD.