5 / 11
Page 19
Notes:
allied
academies
Journal of Neurology and Neurorehabilitation Research | Volume 3
August 23-24, 2018 | Paris, France
Neurology and Neurological Disorders
18
th
International Conference on
Relation of serum levels of homocysteine, vitamin B12 and folate to cognitive functions in Egyptian
Multiple Sclerosis patients
Haidy Elshebawy
Cairo University, Egypt
Background:
Vitamin(B12) and folate have a role in normal
methylation through (folate-vitamin B12-methylation)
pathway which needed for myelin regeneration.
Hyperhomocysteinaemia, vitamin(B12) and folate deficiency
have been linked to cognitive dysfunction in multiple
sclerosis (MS) patients.
Aim:
This study aimed to examine the relation between
serum levels of homocysteine, vitamin(B12), folate and
cognitive functions in Egyptian MS patients.
Methods:
Forty-five clinically definite MS patients and
twenty matched healthy controls were included in the
study. Cognitive assessment done for all participants using
Addenbrooke’s Cognitive Examination III (ACE-III) and trail
making test. Serum levels of homocysteine, vitamin(B12) and
folate were estimated using ELISA technique.
Results:
MS patients showed significant worse performance
in ACE-III and trail making tests compared to controls
(P≤0.001). Serum levels of homocysteine, vitamin(B12) and
folate showed no significant difference between patients
and controls. ACE-III total score showed a significant negative
correlation with homocysteine level (r = -0.692, P ≤ 0.001)
and a significant positive correlation with Vitamin(B12)(r =
0.480, P= 0.001) and folate levels (r = 0.312, P= 0.037).Trail
making test showed a significant positive correlation with
homocysteine level (r = 0.394, P =0.007), and a significant
negative correlation with Vitamin(B12) level (r = -0.345,
P=0.20).By using regression analysis, Homocysteine was
found to be the only significant predictor for cognitive
impairment in MS patients.
Conclusion:
Hyperhomocysteinaemia, vitamin(B12) and
folate deficiency were associated with cognitive impairment
in MS patients. Homocysteine was an independent risk
factor and predictor for cognitive impairment in MS patients.
Speaker Biography
Haidy Elshebawy has completed her PhD at the age of 21 years from faculty of
medicine, Alkasr Alainy Hospitals, Cairo University and received her master’s degree in
neuropsychiatry in May 2014 with excellent degree. She has published her papers and
participated in many national and international conferences.
e:
haidyshebawy@gmail.com