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Journal of Neurology and Neurorehabilitation Research | Volume 3

August 23-24, 2018 | Paris, France

Neurology and Neurological Disorders

International Conference on

Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity

in children with Autism Spectrum disorders

Elham Mousavinejad

Ahvaz Jundishapur University of Medical Sciences, Iran

ntioxidants and oxidative stress can participate in

pathobiochemical mechanisms of autism spectrum

disorders (ASDs). The aim was to identify the effects of early

CoQ10 supplementation on oxidative stress in children with

ASDs. Ninety children with ASDs were included in this study,

based on DSM-IV criteria and using Childhood Autism Rating

Scale (CARS) scores. Concentrations of CoQ10, MDA, total

antioxidant status (TAS) assay, and antioxidant enzymes

(superoxide dismutase or SOD and glutathione peroxidase or

GPx) activity were determined in serum before and after 100

days of supportive therapy with CoQ10 at daily doses of 30 and

60 mg. Data on children’s behavior were collected from parents

and babysitters. CoQ10 supportive therapy was determined

after three months with daily dose 2 ͯ30 mg improved oxidative

stress in the children with ASDs. A relation was seen between

serum MDA (r2 = 0.668) and TAS (r2 = 0.007), and antioxidant

enzymes (SOD [r2 = 0.01] andGPx [r2 = 0.001]) activity andCARS

score. Based on the results, high doses of CoQ10 can improve

gastrointestinal problems (P = 0.004) and sleep disorders (P =

0.005) in childrenwithASDswithan increase in theCoQ10of the

serum. We concluded that the serum concentration of CoQ10

and oxidative stress could be used as relevant biomarkers in

helping the improvement of ASDs.

Speaker Biography

ElhamMousavinejad has completed herMSc in the Department of Biochemistry, School

of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, in 2016, and BSc

DegreeinCommunityNutrition,SchoolofNutritionalSciencesandDietetics,Jundishapur

UniversityofMedicalSciences,Ahvaz,Iranin2006.HerresearchareainvolvedNutritional

Neuroscience and various nutritional deficiencies described in children with ASDs.