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May 16-17, 2019 | Prague, Czech Republic
2
nd
International Conference on
22
nd
International Conference on
Nanomaterials and Nanotechnology
Advanced Nanoscience and Nanotechnology
Joint Event
&
Journal of Materials Science and Nanotechnology | Volume 3
Mater Sci Nanotechnol, Volume 3
Next generation nano antibiotics using C
60
fullerenes
Martin Quirke
Technological University of Dublin, Ireland
T
he objective of my research is to design, synthesise
and tailor a nanoparticle-antibiotic complex capable
of a multi-targeted approach to MDR pathogenic bacterial
infections. A C
60
fullerene complexed with ampicillin had
been designed and characterised via SEM, DLS, PDI, Zeta
potential, UV-Vis, Raman and IR. Post-synthesis the complex
was tested against several strains of bacteria, pathogenic
and non-pathogenic with positive results. The complex could
reduce the quantity of ampicillin to inhibit bacterial growth
for the non-pathogenic strains. The focus of my research is
based on the spectroscopic results obtained via the UV-Vis
and Raman analysis, as well as the microbiological data. As a
result of the spectroscopic analysis, I could observe some very
key characteristics about the complexes growth and potential
point of binding. This was a potential π-π stack formation
between the π electrons on the nano C
60
system and the
aromatic ring on the ampicillin molecule. The deconvoluted
Raman spectra from C
60
and ampicillin showed a drastic
change in the aromatic region. The UV-Vis also showed a
change in the nano region, hypochromic. This is mainly C
60
-C
60
interactions which seems to suggest π-π stack. Couple this
with the increase in stability via zeta and DLS particle growth
would seem to suggest a π system.
e
:
C11806745@student.dit.ie