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Page 59

May 16-17, 2019 | Prague, Czech Republic

2

nd

International Conference on

22

nd

International Conference on

Nanomaterials and Nanotechnology

Advanced Nanoscience and Nanotechnology

Joint Event

&

Journal of Materials Science and Nanotechnology | Volume 3

Mater Sci Nanotechnol, Volume 3

Next generation nano antibiotics using C

60

fullerenes

Martin Quirke

Technological University of Dublin, Ireland

T

he objective of my research is to design, synthesise

and tailor a nanoparticle-antibiotic complex capable

of a multi-targeted approach to MDR pathogenic bacterial

infections. A C

60

fullerene complexed with ampicillin had

been designed and characterised via SEM, DLS, PDI, Zeta

potential, UV-Vis, Raman and IR. Post-synthesis the complex

was tested against several strains of bacteria, pathogenic

and non-pathogenic with positive results. The complex could

reduce the quantity of ampicillin to inhibit bacterial growth

for the non-pathogenic strains. The focus of my research is

based on the spectroscopic results obtained via the UV-Vis

and Raman analysis, as well as the microbiological data. As a

result of the spectroscopic analysis, I could observe some very

key characteristics about the complexes growth and potential

point of binding. This was a potential π-π stack formation

between the π electrons on the nano C

60

system and the

aromatic ring on the ampicillin molecule. The deconvoluted

Raman spectra from C

60

and ampicillin showed a drastic

change in the aromatic region. The UV-Vis also showed a

change in the nano region, hypochromic. This is mainly C

60

-C

60

interactions which seems to suggest π-π stack. Couple this

with the increase in stability via zeta and DLS particle growth

would seem to suggest a π system.

e

:

C11806745@student.dit.ie