materials-summit-separation-summit-2018-posters

Page 49

O c t o b e r 1 9 - 2 0 , 2 0 1 8 | T o k y o , J a p a n

Materials Summit 2018 & Separation Summit 2018

Materials Science and Nanotechnology

Volume 2

ADVANCED MATERIALS AND POLYMER SCIENCE

SEPARATION TECHNIQUES

International Conference on

International Conference and Expo on

Joint Event on

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

Mater Sci Nanotechnol 2018, Volume 2

ENANTIO-RESOLUTION OF (+)- BUPROPION BY REVERSED PHASE

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY USING CYANURIC

CHLORIDE BASED CHIRAL DERIVATIZING REAGENTS HAVING AMINO

ACIDS AS CHIRAL AUXILIARIES

Sonika Batra

and

Ravi Bhushan

GD Goenka University, India

nantio-separation of (+)- bupropion was achieved as its diastereomers which were prepared with chiral derivatizing reagents

(CDRs) synthesized from cyanuric chloride. Two sets of CDRs each consisting of five CDRs were prepared by nucleophilic

substitution of Cl atom in cyanuric chloride with amino acids (namely, L Leu, L Val, L Phe, D Phg and L Ala) as chiral auxiliaries

to give dichloro-s-triazine (DCT) and other five new CDRs were prepared by nucleophilic substitution of Cl atom in 6 butoxy

derivative of cyanuric chloride with the above mentioned amino acids. The diastereomers were synthesized under microwave

irradiation for 70 or 90s at 80% power and by conventional heating method. Separation of diastereomers was achieved using C

column and an isocratic eluting mixture of acetonitrile and aqueous trifluoroacetic acid. Separation efficiencies of the two sets

of CDRs, among themselves and among the two groups, have been compared based on resolution (Rs) and difference between

the retention times of resolved diastereomers. The method was validated for detection limit, linearity, accuracy and precision.