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Journal of Materials Science and Nanotechnology | Volume 3
October 07-08, 2019 | Frankfurt, Germany
Materials Science and Engineering
3
rd
International Conference on
Mater Sci Nanotechnol, Volume 3
Plasmonic nanostructures for imaging and targeting drug delivery
Oara Neumann
Rice University, USA
E
ngineering a compact, near-infrared plasmonic
nanostructure with integrated image-enhancing agents for
combined imaging and therapy is an important nanomedical
challenge. To overcome this challenge we designed a
nanostructure with NIR plasmonic signatures composed of
a 50 nm Au core surrounded a SiO2 inner-shell doped with
contrast agents and an outer Au shell. The plasmon resonance
of this nanostructure, known as a nanomatryoshka (NM), can
be tuned to the desiredwavelength by varying the thickness of
the layers. The encapsulated contrast agents used in this study
are: Fe(III)-DOTA, Gd(III)-DOTA, and fluorescent dyes. The
Fe(III)-NM based contrast agents are found to have relaxivities
two times greater than the widely used Gd(III)-DOTA,
providing a practical alternative for T1MRI contrast agent that
eliminates Gd(III) patient exposure entirely. Additionally, the
internalization of fluorescent dyes and MRI contrast imaging
agents within the NM substantially reduces the toxicity while
maintaining a free nanoparticles surface for further bio-
functionalization.
e
:
on4166@rice.edu