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Journal of Materials Science and Nanotechnology | Volume 2
July 23-25, 2018 | Moscow, Russia
Materials Science and Engineering
International Conference on
Microstructure and mechanical behavior of Zr–Mo Biomedical alloys
Éder Sócrates Najar Lopes and Anderson K Suzuki
University of Campinas, Brazil
Zr-Mo alloys show low elastic modulus and low magnetic
susceptibilities which are ideal for biomedical applications.
In this work Zr-xMo (x = 0, 1, 3, 7.5, 10, and 15 wt.%) alloys
were investigated. Ingots were arc melted and subjected to
homogenization heat treatment, hot rolling process, solution
heat treatment followed water quenching. Water quenched
samples were characterization by XDR, visible light microscopy,
andVickershardness.Microstructuralresults(i.e.XRDandvisible
light microscopy) showed that the martensite α′ phase was the
dominant form for pure Zr and Zr-1Mo content in the water
quenched alloys. The β and ω phases were formed in Zr–3Mo
alloyswhileonlyβphasewasobservedinZr-7.5MoandZr-10Mo.
The Mo2Zr compound was observed in Zr-15Mo alloy. Vickers
hardness results showed the lowest value for pure Zr samples
(174 HV) whereas Zr-3Mo (β + ω phases) presents the higher
hardness (440 HV) due the brittle ω phase. High β-stabilizer
samples Zr-7.5 to Zr-15Mo showed values around 300 HV.
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Multifunctional Micro and Nanoencapsulation approaches with remote controlled delivery and release
properties
Gleb B Sukhorukov
Queen Mary University of London, UK
One of the challenges in the (bio)-nanotechnology field
is development of micro or nano-sized delivery systems
comprising different functionalities. These systems should be
able to ship and to carry bioactive substances to pre-defined site
and unload it in designed time and place predominantly with
remote physical signalling. Layer-by-layer assembled capsules
have been intensively studied in recent years owing to their
ability to encapsulate a wide range of chemicals from complex
biomacromolecules to small water-soluble compounds, for
their permeability to be modified and their responsiveness
to different factors and functionalities to be tailored in one
capsule entity. Current research leads to the fabrication of
carriers with remote guiding and activation by optical, magnetic
and ultrasound addressing, what envisages unique applications
as multifunctional biomaterials, including intracellular entering
and in-vivo delivery with remote controlled release of micro
packaged (bio)-chemicals. Release and encapsulation of
materials by light and/or ultrasound and their navigation with
magnetic field is a particularly interesting topic for chemical
and biomedical applications. Microcapsules display a broad
spectrumof qualities over other existingmicro delivery systems
such as high stability, longevity, versatile construction and
geometry of micropackeging and a variety of methods to retain
and release the substances. The talk highlights recent advances
in polyelectrolyte multilayers relevant to in vivo delivery of
capsule to side of interest by magnetic field as well as make the
cells magnetic upon their uptake by various cells lines. Another
particular attention in areas of polyelectrolyte multilayers is
given on formation of defined microstructures on patterned
surfaces. Polyelectrolyte multilayers can be deposition onto
widely used PDMS stamps forming, so called, microchamber
arrays enabled to accommodate various biologically active
molecules. These chambers can be sealed over with another
thin made of polymeric layers and resulted structure is pulled
off to form free standing microchambers. Entrapment of
water soluble molecules into sealed chambers is performed
by depositing hydrophobic layer polylactic acid on the top
of multilayers and water-soluble molecule make precipitate
inside wells upon drying. Sealing results on formation of
microsized air-bubble what can keep water soluble molecules
inside the chamber until it released upon remote signalling
via ultrasound or light. The perspectives of biomedical
application of remote activation and microchambers and
capsule delivery and microchamber activation are discussed.
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