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Journal of Gastroenterology and Digestive Diseases | Volume 3
May 25-26, 2018 | New York, USA
World Liver Conference 2018
C
urrent pharmacological studies on medicinal plants,
animal, mineral based raw material, pure or compound
chemical substances of Mongolian traditional medicine are
identifying their biological active components thus, linear
cell growth, pharmacogenomics, proteomics and clinical
studies shown positive results on their treatment rate.
Alcohol induced chronic hepatitis are broad epidemic disease
worldwide, as the pathogenesis of the Alcohol hepatitis
deteriorates it leads to serious health complications such
as hepatic steatosis, cirrhosis, hepatocellular carcinoma,
thus alcohol hepatitis has a critical impact on economics
and population health. Epidemiological research conducted
on alcohol induced hepatitis shown results of mortality rate
of the disease decreasing last couple of years. Our team of
researchers has chosen the topic basing on current wide
usage of the Gurgum-7 traditional compound on hepatic
disorders and its indication of relieving symptoms of hepatic
fever, toxicities, jaundice, injuries thus administering to a
patients with alcohol induced hepatitis under the aim of
proving the results with modern scientific methods. As the
results after the experimentation and research according
to the GHS classification the hepatotoxic characteristic of
Gurgum-7 is relatively low. The result shown 160 mg/kg dose
of Gurgum-7 is more efficient on lowering AST, ALT enzymes
at 28th week of chronic ethanol toxicity, Comparing the
quantity of Malondialdehyde (10.73±0.68) of a second group
of the test animals which administered 160 mg/kg with
control group shown statistically relevant (p≤0.05) therefore
18.46% reductions of the enzymes. Also, a group of test
animals which administered Gurgum-7 by 160 mg/kg dosage
showed the result of difference of statistically relevant
(p≤0.05) which is more close to the healthy group. These
results tell us the Gurgum-7 has an antioxidant effect. First
stage of clinical study Gurgum-7 showed no side effects and
liver, kidney functions are remained healthy. Second stage
of the clinical study showed the decreases on laboratory
test results of the main and control groups as ALT 52.3%
(p<0.01), AST 45.5% (p<0.01), gamma glutamyltransferase
43.9% (p<0.01) thus indicating the compound is decreasing
the breakdown of hepatocytes, bile duct obstruction during
alcohol hepatitis and toxicity. Blood coagulation test showing
the Gurgum-7 is decreasing the breakdown of hepatocytes
therefore effecting blood clotting factors including I, II,
V, VII, X, fibrinogen, protrombine, vitamin K deficiency
positively. The decrease of hepatocyte breakdown leads to
the regaining of the normal liver function and blood clotting
factor II, V, X so the blood coagulation disorders are fixed.
Therefore, we are connecting the result mentioned above
to a short course of treatment. Because of the short course
of treatment it may have not showed any difference on
macro structure level, as identifying the liver fibrosis rate
by APRI method before and after the treatment, Gurgum-7
effectively decreasing liver fibrosis.
Speaker Biography
Bayarsaikhan O has completed his MSc from MNUMS, Mongolia. He is the Teacher
of University MNUMS, Mongolia. He has over 16 publications with citations over 16
times.
e:
dgbsuren@gmail.comEffect of the gurgum-7 traditional compound on alcohol induced chronic hepatitis
Bayarsaikhan O, Badamsuren D, Tserendagva D, Tsend-Ayush D, U Buyan
and
Kherlen P
School of Traditional Medicine, Mongolia