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Page 58
allied
academies
Journal of Gastroenterology and Digestive Diseases | Volume 3
May 25-26, 2018 | New York, USA
World Liver Conference 2018
T
he induction of endogenous adult stem cells by
administering
soluble
molecules
provides
an
advantageous approach for tissue damage repair, which
could be a clinically applicable and cost-effective alternative
to transplantation of embryonic or pluripotent stem cell-
derived tissues for the treatment of acute organ failures.
Here we show that HGF/Rspo1 induce liver stem cells to
rescue liver dysfunction. Carbon tetrachloride treatment
causes both fibrosis and Lgr5+ liver stem cell proliferation,
whereas Lgr5 knockdown worsens fibrosis. The Injection of
HGF in combination with Rspo1 increases the number Lgr5+
liver stem cells and improves liver function by attenuating
fibrosis. We observed Lgr5+ liver stem cells in human liver
fibrosis tissues, and once isolated these cells were able to
form organoids, treatment with HGF/Rspo1 promoted their
expansion. We suggest that Lgr5+ liver stem cells represent
a valuable target for liver damage treatment and that HGF/
Rspo1 can be used to promote liver stem cell expansion.
HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells
Yuan Lin
and
Wei-Jie Zhou
Southern Medical University, China