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allied
academies
Journal of Gastroenterology and Digestive Diseases | Volume 3
May 25-26, 2018 | New York, USA
World Liver Conference 2018
Background:
Hepatitis infection has become a major
worldwide health problem because the potential nature
of course of the disease to cirrhosis and the hepatocellular
carcinoma (HCC). Acute viral infection is the most common
cause of all forms of hepatitis. The viral hepatitis have been
thought to be self-limiting in nature but sometimes majority
of patients of viral hepatitis have been observed ending up
with a serious complications like hepatic failure, etc. So, the
clinical study was planned to evaluate the hepatoprotective
effect of
Bhyumyamalki (Phyllanthus amarus)
and
Phaltrikadi
decoction (an Ayurvedic herbal composition) on scientific
parameters.
Aimandobjectives:
Toclinicallyevaluatethehepatoprotective
effect of
Bhyumyamalki (Phyllanthus amarus)
and
Phaltrikadi
decoction in patients of acute viral hepatitis.
Materials and Methods:
This prospective, clinical trial
was conducted at Department of Medicine, Desh Bhagat
Ayurvedic College & Hospital, Mandi Gobindgarh, Punjab.
Only those patients were selected for clinical trial, who
presented themselves with anorexia, nausea, vomiting,
low grade fever, weakness, dark urine, jaundice and tender
hepatomegaly with abnormal liver function test (LFTs). Each
patient was subjected to series of laboratory tests such
asserum bilirubin, AST, ALT, serum alkaline phosphatase,
HbSAg, HCV and liver ultrasound before treatment, after 15
days of treatment and after one month of treatment to know
the extent of liver damage as well as the rate of response to
trial drugs. In the clinical trial, three groups of patients of viral
hepatitis have been studied to evaluate the hepatoprotective
effect of
Bhumyamalki and Phaltrikadi
decoction. The first
group was given 50 ml of freshly prepared Bhumyamalki
decoction, made from 10 gm of crude drug, twice daily. The
second group was given a standardized decoction of herbal
composition
Phaltrikadi
decoction, in a dosage of 50 ml
made from 10 gm of crude drug, twice daily. The third group
was given 100 gm of glucose powder daily.
Observations and Results:
The trial was conducted for one
month and liver functions test were periodically evaluated
to assess the hepatoprotective effect of drugs under trial.
At the end of the trial, group first and second exhibited
hepatoprotective efficiency over the control.
Conclusion:
Thus it can be concluded that
Bhumyamalki and
Phaltrikadi
decoction drugs are effective in the management
of acute viral hepatitis.
Clinical evaluation of hepatoprotective effect of
Bhumyamalki (Phyllanthus amarus)
and
Phaltrikadi
decoction (an ayurvedic herbal composition) in patients of acute viral hepatitis
Harbans Singh
Central Ayurveda Research Institute for Respiratory Disorders, India