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Journal of Gastroenterology and Digestive Diseases | Volume 3
May 25-26, 2018 | New York, USA
World Liver Conference 2018
A
cute on chronic liver failure (ACLF) is a distinct clinical
syndrome characterized by liver failure due to an
acute hepatic injury on an underlying chronic liver disease
with high 28-day mortality. Acute insults include alcohol,
hepatotropic viruses, and drugs whereas the underlying
chronic liver disease is cirrhosis due to alcohol, hepatitis B
or C, or NASH. After an acute insult, persistent inflammation,
systemic inflammatory response syndrome and the cytokine
storm have a central role in the pathogenesis of liver failure
and subsequent organ failure. Abstinence, antiviral therapy,
and withdrawal of harmful drug are specific therapies that
could help ameliorate or reverse the liver failure. Liver
transplantation is the definitive treatment, and a good
outcome is achieved with early transplantation in carefully
selected patients; liver dialysis and plasmapheresis can
help as ‘bridge therapies.' What about the magnitude of
the problem in the Middle East and Africa? Is there any
difference between the definitions of ACLF, risk factors, and
presentations in different parts of the world?
e:
salemyousefmohamed@gmail.comAcute‑on‑chronic liver failure (ACLF)
Salem Y Mohamed
Zagazig University, Egypt