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Archives of General Internal Medicine | Volume 2

April 04-05, 2018 | Miami, USA

International Conference on

Internal Medicine & Practice and Primary Care

International Meeting on

Breast Pathology & Cancer Diagnosis

Introduction

: There is increasing evidences that favor

the prenatal beginning of schizophrenia. These evidences

point toward intra-uterine environmental factors that

act specifically during the second pregnancy trimester

producing a direct damage of the brain of the fetus. The

current available technology doesn’t allow observing what

is happening at cellular level since the human brain is not

exposed to a direct analysis in that stage of the life in subjects

at high risk of developing schizophrenia.

Methods

: In 1977, we began a direct electron microscopic

research of the brain of fetuses at high risk fromschizophrenic

mothers in order to finding differences at cellular level in

relation to controls.

Results

: In these studies, we have observed within the nuclei

of neurons the presence of complete and incomplete viral

particles that reacted in positive form with antibodies to

herpes simplex hominis type I [HSV1] virus, andmitochondria

alterations.

Conclusion

: The importance of these findings can have

practical applications in the prevention of the illness

keeping in mind its direct relation to the aetiology and

physiopathology of schizophrenia. A study of amniotic fluid

cells in women at risk of having a schizophrenic offspring

is considered. Of being observed the same alterations that

those observed previously in the cells of the brain of the

studied fetuses, it would intend to these women in risk of

having a schizophrenia descendant, previous information

of the results, the voluntary medical interruption of the

pregnancy or an early anti HSV1 viral treatment as preventive

measure of the later development of the illness.

Direct evidence of viral infection and mitochondrial alterations in the brain of fetuses at high risk for

schizophrenia

Segundo Mesa Castillo

Psychiatric Hospital of Havana, Cuba