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allied
academies
Archives of General Internal Medicine | Volume 2
&
April 04-05, 2018 | Miami, USA
International Conference on
Internal Medicine & Practice and Primary Care
International Meeting on
Breast Pathology & Cancer Diagnosis
S
tudies in some sub-Saharan African countries like
Zimbabwe, Malawi, Kenya and Gambia revealed that
Group
B Streptococcus
(GBS) is emerging as the main cause
of neonatal sepsis and meningitis. However, in Nigeria,
information on GBS disease prevalence remains sparse. We
sourced to isolate GBS from the rectovaginal and neonatal
samples that were obtained from a tertiary hospital in
a populated area of Osun state and give an updated
information on the antibiotic susceptibility patterns, using
demographic and clinical parameters. One hundred and
seventy samples were collected from consenting mothers
and neonate from June 2016 to January 2017. Ninety-Eight
(98) GBS isolates were recovered from vaginal, rectal of
the pregnant woman at the point of labour and Umbilical
cord of the neonate within 24hrs of birth. cultures for
the isolation and identification of Group B Streptococcus
(GBS) were carried out using the CDC recommended
microbiological methods. The Kirby Bauer disk-diffusion
method was mployed to determine antibiograms of GBS
isolates in accordance with Clinical and Laboratory Standards
institute(CLSI). The presence of resistant genes was examined
using PCR . The prevalence rate of GBS maternal and
neonatal colonization were 29.4% and 20.6% respectively
while 4% of the colonized neonates had nosocomial GBS
colonization. There was no significant association between
GBS colonization status and age (p >0.05)), parity (p >0.05),
obstetric risk factors (p >0.05) and sex of neonate. There
was no incidence of GBS infection observed. Resistance to
augmentin (88.8%), ampicillin (60.2%), penicillin (47%),
tetracycline (34.7%), ceftriaxone (19.4%), clindamycin
(13.3%), vancomycin (10.2%) and erythromycin (7.1%) were
observed. one of the 8 representatives of the multidrug
resistant isolates harboured tetM gene while other resistant
genes examined were negative in all MDR isolates. High
prevalence of maternal and neonatal GBS colonization has
been established among pregnant women and neonates in
the study area. Nosocomial infection was implicated in GBS
colonization among neonates. However further research is
called for using larger sample size and multiple curve studies
for adequate extrapolation into the general population.
e:
omololu-aso@oauife.edu.ngGroup B streptococcus infection among pregnant women and neonatal colonization rate in patients
from Obafemi Awolowo University teaching hospital complex, South western Nigeria
J Omololu-Aso
Obafemi Awolowo University, Nigeria