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alliedacademies
Archives of General Internal Medicine | Volume 2
&
April 04-05, 2018 | Miami, USA
International Conference on
Internal Medicine & Practice and Primary Care
International Meeting on
Breast Pathology & Cancer Diagnosis
Breast cancer is one of the most common environmental
malignancies and second cause of cancer related death in
developed countries. Mitochondria are a “power house” and
a “canary in a coal mine” of human cancer cells. NRF1 is a
master regulator of mitochondrial biogenesis. Mitochondrial
biogenesis and translation are dysregulated in the breast
cancer cells; this mitochondrial dysfunction enhances
tumorigenicity and metastatic potential. Identifying
therapeutic targets for management of both tumoral
mitochondrial biogenesis and mitophagy is critical to
suppress tumorigenesis. This literature review summarizes
the role of mitochondria in breast cancer, estrogen-induced
oxidative stress on NRF1 up regulation with tumoral
mitochondrial biogenesis and mitophagy and potential
therapeutic modalities.
e:
Estrogen induced oxidative stress, NRF1, tumoral mitochondria and potential therapeutic modalities,
literature review
S Silverman
Misericordia Community Hospital, Canada