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Curr Trend Cardiol. 2017 | Volume 1 Issue 3
September 18-19, 2017 | Toronto, Canada
Annual Conference on
HEART DISEASES
Objectives:
To explore the association between the AQP7,
AQP9 genes polymorphisms in patients with hypertension
and the risk of stroke in Chinese; and the possible gene-gene
and gene-environment interactions.
Methods:
The stroke cases and the patients with
hypertension were recruited from the follow-up cohort
study of hypertension which established in 2010 in Jiangsu
Province. The patients with stroke for the first time during
the past 6 years were the cases groups, the patients with
hypertension were the control groups which were chosen
according to the inclusion criteria (paired with each stroke
case): same gender, the age between ±3 years, the same
place of residence, and the rate of case and control was
1:3. Genotyping of 5 SNPs in AQP7 (rs2989924, rs3758269,
rs2542743) and AQP9 (rs57139208, rs16939881) was
performed by the polymerase chain reaction assay.
Results:
The results of single SNP analysis showed that
rs2989924 was associated with the risk of stroke in this case-
control study, the frequency distribution was statistically
significant; compared to AA+AG genotype, GG genotype
significantly increased the risk of stroke, with an adjusted OR
of 1.741(95% CI: 1.232-2.461). After adjusted confounders,
CC+TT genotype of rs3758269 can decreased the risk of
stroke, with an adjusted OR of 0.669 (95% CI: 0.450-0.994),
compared to CC genotype. Based on the stratified analysis,
recessive genotype model of rs2989924 significantly
increase the risk of stroke in male, over 60 years old, BMI(kg/
m2)≥25, and central obesity in hypertension patients, with
an adjusted OR of 2.23 (95% CI:1.32-3.77), 2.20(95% CI:1.41-
3.44), 2.35(95% CI:1.45-3.81) and 1.81(95% CI:1.22-2.70).
Before adjusted confounders rs3758269 has nothing to do
with the stroke, but after adjusted confounders, rs3758269
was associated with decreased risk of stroke in over 60 years
old and BMI(kg/m2)≥25, with an adjusted OR of 0.48(95%
CI:0.25-0.94) and 0.43(95% CI:0.24-0.77) in dominant
genotype model. No gene-gene interaction and linkage
disequilibrium were observed.
Conclusions:
SNPs rs2989924, rs3758269 were associated
with the risk of stroke in Chinese Han population. No
association between rs2542743, rs57139208, rs16939881
and the risk of stroke was found.
Speaker Biography
Xiang Quanyong, Professor of Nanjing Medical University, Southeast University, is
now working in the Department of Chronic non-communicable Disease Control and
Prevention, Jiangsu Province Center for Disease Control and Prevention, China, deputy
director of the department. He is a member of Chinese Hypertension Federation. His
current main research activities are: 1) monitoring and analyzing of the prevalence of
cardiovascular and cerebrovascular diseases, especially the control and prevention of
Hypertension; 2) Diabetes control and prevention; 3) control and prevention of the
risk factors for non-communicable disease, especially for Tobacco Control. He has
published several papers in International Journal, Such as: Arch Toxicol, J Hum Genet,
Oncotarget, J Diabetes Res, and so on.
e:
xiangquanyong@126.comCohort study on the association between the AQP7, AQP9 gene polymorphisms in patients with
hypertension and the risk of stroke
Quanyong Xiang
1,2
, Li Yan
2
, Qiushi Wang
2
and
Yu Qin
1
1
.Jiangsu Center for Disease Control and Prevention, China
2
.School of Public Health, Southeast University , China