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Curr Trend Cardiol. 2017 | Volume 1 Issue 3
September 18-19, 2017 | Toronto, Canada
Annual Conference on
HEART DISEASES
Backgrounds and aims: Cholesterol 7α hydroxylase encoding
by gene CYP7A1 is the initial and rate-limiting step in the
classical bile acid synthesis pathway. Atorvastatin can markedly
upregulate the mRNAs of bile acids synthetic enzymes
CYP7A1 in the liver to increase fecal bile acid excretion. We
tempt to investigate the association between a novel CYP7A1
polymorphism rs8192875 and reduction of lipid levels response
to atorvastatin in Chinese patients with coronary artery disease.
Methods: Of 169 patients with coronary artery disease
were treated with atorvastatin for one month. Lipid profiles,
including triglycerides(TGs), total cholesterol(TC), low-
density lipoprotein cholesterol(LDL-C), and high-density
lipoprotein cholesterol(HDL-C) were determined before and
after treatment. Rs8192875 genotypes were assayed with
the iPLEX assay in conjunction with the MassARRAY platform.
We performed independent sample t test or Kruskal-Wallis
test to evaluate the effects of SNP.
Results: After one month of atorvastatin therapy, the lipid
levels decreased significantly. Compared with AG genotype,
the GG genotype of rs8192875 achieved a greater reduction
of LDL-C level (0.694±0.701 vs. 0.136±0.401 mmol/l,
p=0.0056; 24.090±23.104% vs. 2.182±20.809%, p=0.0031);
and a similar pattern of efficacy appears to TC (0.808±0.791
vs. 0.302±0.381 mmol/l, p=0.0208; 16.410±15.370% vs.
6.936±9.711%, p=0.0341).The genotypes had no significant
difference on TGs or HDL cholesterol-lowering response to
atorvastatin.
Conclusions: A novel CYP7A1 exon variant rs8192875 is
significantly associated with reducing LDL-C and TC level
response to atorvastatin.
Speaker Biography
Jing Chen completed her Master’s degree in Epidemiology and Hygenic statistics
from School of Public Health, Peking University Health Science Center in 2016. She
participated in a research study at Shi Mao Group Charity Hospital Research as an
investigator. Her other research experiences include- National Free Preconception
Health Examinaton Project (NFPHEP) during, The Family Based Cohort Study on
The Common Non-communicable Chronic Diseases of the Population in The Rural
Community of Northern China during and WHO project on “To promote the quality of
Chinese maternal and child health annual report research”.
e:
A novel CYP7A1 polymorphism is associated with the low-density lipoprotein cholesterol response to
atorvastatin
Jing Chen 1, Zhi-Ke Liu, 2 Da-Fang Chen, 2
1Peking University Six Hospital, China
2Peking University Health Science Center, China