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Curr Trend Cardiol. 2017 | Volume 1 Issue 3
September 18-19, 2017 | Toronto, Canada
Annual Conference on
HEART DISEASES
Background:
Diabetes mellitus is a chronic disease and
correlates to the future major adverse cardiovascular events.
Perivascular Adipose Tissue (PVAT) is an important site of
regulating vascular dysfunction in diabetes. Polysaccharides
Peptides (PsP), extract of
Ganoderma lucidum
, is one of
the antioxidant therapies which is currently developed as
complimentary diabetes therapy. This study was conducted
to determine effect of PsP as an antioxidant agent to inhibit
the thickness of perivascular adipose tissue (PVAT) in diabetic
model rats.
Methods:
It was an experimental study with post-test only
on control group design on male rats
Rattus norvegicus
aged
8 weeks. We administered high fat diet (HFD) and low-dose
streptozocin (STZ) to make them diabetics, followed by PSP
for 4 weeks. Samples were collected from rat aortic arch slice
and then were read using light microscope.
Results:
One-way ANOVA analysis showed that there is
significant difference of vascular intimal-media thickness
in at least two treated groups (p=0.000). Post Hoc analysis
with LSD showed that PsP with dose 150 mg/kgBW and 300
mg/kgBW can inhibit atherosclerotic process and reducing
vascular intimal-media thickness into the condition of
approaching normal group. Based on Pearson correlation
test, there was a sufficiently strong correlation between
PVAT thickness in negative control group and diabetic model
rats with PsP 150 mg/kgBW group.
Conclusion:
Administration of PsP was proved to decrease
the vascular intimal-media thickness diabetic model rats. The
dose of 150mg/kgBWof PsP is the optimal dose in decreasing
the vascular intimal-media thickness in diabetic model rats.
Besides, PsP also decreases the Perivascular Adipose Tissue
(the PVAT) thickness and acts as an antioxidant.
Speaker Biography
Djanggan Sargowo, MD, PhD, FIHA, FACC, FESC, FAPSC, FAsCC, FINASIM, is a Professor
at the University of Brawijaya, and is board certified in Internal Medicine and
Cardiovascular Disease. His clinical interests include management of ischemic heart
disease, congestive heart failure, hypertension, diabetes mellitus, dyslipidemia and
peripheral vascular disease. He received his MD from University of Gadjah Mada,
Yogyakarta, Indonesia. He received training in Internal Medicine at Airlangga University
and Cardiology at University of Indonesia. He received his PhD degree in Medicine from
University of Airlangga. In the past, Barry served as Head of Cardiology and Vascular
Department at Dr. Saiful Anwar General Hospital Malang and Director of Postgraduate
Program at University of Brawijaya. He is currently a Fellow of Indonesian Heart
Association, a Fellow of the American College of Cardiology, a Fellow of the European
Society of Cardiology, a Fellow of Asia Pacific Society of Cardiology, a Fellow of ASEAN
Federation of Cardiology, and a Fellow of Indonesian Society of Internal Medicine.
He serves as Director of Brawijaya University Teaching Hospital, Chairman of Malang
Molecular Biology Institute and as Chairman of Center for Degenerative Diseases,
Brawijaya University.
e:
djanggan@yahoo.comTheeffect of polysaccharides peptides
Ganoderma lucidum
to intimal-media thickness andperivascular
adipose tissue in type-2 diabetic model
Rattus norvegicus
strain wistar
D Sargowo, T A Wihastuti, F I Puspitasari, I Kharisma, O Handayani
and
L H Adrian
University of Brawijaya, Indonesia