health-cardiac-surgery-2018-posters-abstracts

Page 50

allied

academies

August 27-28, 2018 | London, UK

International Conference on

Healthcare and Health Management

Cardiology and Cardiac Surgery

Joint Event

Journal of Public Health Policy and Planning | Volume: 2

Direct evidence of viral infection and mitochondrial alterations in the brain of

fetuses at high risk for Schizophrenia

Segundo Mesa Castillo

Psychiatric Hospital of Havana, Cuba

here is increasing evidences that favor the prenatal

beginning of schizophrenia. These evidences point toward

intra-uterine environmental factors that act specifically during

the second pregnancy trimester producing a direct damage of

the brain of the fetus. The current available technology doesn’t

allow observing what is happening at cellular level since the

human brain is not exposed to a direct analysis in that stage

of the life in subjects at high risk of developing schizophrenia.

Methods. In 1977 we began a direct electron microscopic

research of the brain of fetuses at high risk from schizophrenic

mothers in order to finding differences at cellular level in

relation to controls. Results. In these studies we have observed

within the nuclei of neurons the presence of complete and

incomplete viral particles that reacted in positive form with

antibodies to herpes simplex hominis type I [HSV1] virus, and

mitochondria alterations. Conclusion. The importance of these

findings can have practical applications in the prevention of

the illness keeping in mind its direct relation to the aetiology

and physio pathology of schizophrenia. A study of the

gametes or the amniotic fluid cells in women at risk of having

a schizophrenic offspring is considered. Of being observed the

same alterations that those observed previously in the cells

of the brain of the studied fetuses, it would intend to these

women in risk of having a schizophrenia descendant, previous

information of the results, the voluntary medical interruption

of the pregnancy or an early anti HSV1 viral treatment as

preventive measure of the later development of the illness.