gastroenterologists-2018-accepted-abstracts

Page 22

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academies

Nov 15-16, 2018 | Paris, France

Gastroenterology and Digestive Disorders

International Conference on

Journal of Gastroenterology and Digestive Diseases | Volume 3

Volatile organic metabolites as novel, non-invasive diagnostic biomarkers of Gastrointestinal disorders

Iftikhar Ahmed

University of Southampton, UK

he Diagnosis of Gastrointestinal (GI) disorders requires

extensive and often invasive investigations including

Colonoscopy and histology and places a heavy burden, both on

healthcare resources, because of the cost, and on the individual,

in times of disease-related disability and poor quality of life.

Recently, there has been increasing interest in non-invasive

Biomarkers to diagnose different GI diseases and to monitor

the disease activity. There is growing scientific interest in the

investigation of volatile metabolites and numbers of studies

have focused on the utilization of Non-Invasive Biomarkers in

the diagnosis of GI disease.

The development of sophisticated analytical techniques has

enabled the study and interpretation of changes in the faecal

and breath Volatile Organic Metabolites (VOMs) and its

correlation with the pathophysiological mechanisms in the GI

diseases. VOMs are the chemicals that are the products and

intermediates of metabolism and may be altered during the

diseases process. Changes in the signature of VOMs could

potentially provide diagnostic information about health and

disease. Multiple studies have reported the differences in VOM

profiles of healthy controls vs. patients with liver and other GI

disorders. VOM profiles have been used to segregate patients

by disease activity and the type of disease. The correlation of

VOMswithmicrobiota is interestingandsupports thehypothesis

of gut microbial dysbiosis in the etiology of liver disease. This

provides an important platform to explore the role of dysbiosis

in liver and other GI disorders pathogenesis and development

of novel therapeutic targets. In future, further understanding of

faecal VOMsmay lead to the development of a rapid and simple

point of care diagnosis and monitoring of Liver.