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allied
academies
Nov 15-16, 2018 | Paris, France
Gastroenterology and Digestive Disorders
International Conference on
Journal of Gastroenterology and Digestive Diseases | Volume 3
Fecal microbiota transplantation is a rescue treatment modality for refractory Ulcerative Colitis
Ahmet Uygun
University of Health Sciences, Turkey
F
aecal Microbial Transplantation (FMT) provides to
replace beneficial bacteria with more favourable
Microbiomes in recipient with dysbiosis. The aim of the
present study was to prospectively investigate the efficacy
of FMT by assessing the clinical and endoscopic response
in patients with Ulcerative Colitis (UC) who had failed anti-
inflammatory, immunosuppressive and TNF-α inhibitors
(Infliximab, Adalimumab) and therapy. In this prospective and
uncontrolled study, 79 patients with UC were included. All
medications except Mesalazine were stopped 1 weeks before
FMT. Colonoscopy was performed both before and after FMT.
To assess the efficacy of FMT, Mayo scores were calculated at
week 0 and week 24. A total of 500 ml extracted fresh faecal
suspension was administered into the 30 to 40 cm proximal
of terminal ileum of recipients. FMT could be considered as
a promising rescue treatment modality before surgery in
patients with refractory UC. Besides, although the long-term
results are unknown, FMT also appears to be definitely safer
and more tolerable than the Immunosuppressive and TNF-α
inhibitors (Infliximab, Adalimumab) therapy in patients with
UC.
e:
ahmetuygun62@hotmail.com