gastroenterologists-2018-accepted-abstracts

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allied

academies

Nov 15-16, 2018 | Paris, France

Gastroenterology and Digestive Disorders

International Conference on

Journal of Gastroenterology and Digestive Diseases | Volume 3

Transplantation for Hepatocellular Carcinoma is there a Tumor size limit?

Amany Sholkamy

Cairo University Kasr AlAiny, Egypt

he advent of tumor size-based criteria (Milan and UCSF)

for transplantation of Hepatocellular carcinomas (HCC)

has facilitated access of tumor patients to transplantation.

Recent success in transplanting patients with larger tumors

(beyond UCSF) necessitates understanding of patient, tumor

and biological criteria that determine successful outcome for

HCC Transplantation across all size

analysed 11,928

patients who received OLT from 2002 till 2013 from the UNOS

star file. Clinical outcomes were compared by tumor size at

transplant;Milan (N=11555), beyondMilanwithinUCSF (N=291)

&beyondbothMilan&UCSF(N=82).Statisticalanalysiswasdone

todetermine factors impacting survival. Thesedata indicate that

based on current clinical selection criteria a small number of

large tumors canbe successfully treatedby transplantation, and

points to the need to include markers of HCC biologic behavior

beyond size and tumor burden to transplant criteria.