gastroenterologists-2018-accepted-abstracts

Page 31

Notes:

allied

academies

Nov 15-16, 2018 | Paris, France

Gastroenterology and Digestive Disorders

International Conference on

Journal of Gastroenterology and Digestive Diseases | Volume 3

A study on anti-inflammatory effects of acetly-11-keto-β-boswellic acid against dextran sodium

sulphate induced Colitis in mice

Antara Banerjee

Allied Health Sciences, India

lcerative colitis (UC) is an autoimmune, idiopathic, and

inflammatory disorder which affects the lining of the

colon and the rectum. UC involves the enhanced disruption

of extracellular matrix and obstruction of the mucosal barrier

with production of inflammatory cytokines, reactive oxygen

species, enzymes, growth factors, etc. Unconventional

strategies have consequently been investigated, establishing

the use of naturally occurring ingredients whichmight present

potential therapeutic properties for the treatment of chronic

disorders including UC. One such agent is acetyl-11-keto-beta-

boswellic acid (AKBA), an active derivative of the gum resin

extract of Boswellia serrata. The present study investigated

the anti-inflammatory effect of AKBA against dextran sulfate

sodium (DSS) induced colitis in mice. To verify attenuation of

DSS induced damage by AKBA, disease activity index (DAI) and

body weight changes were monitored daily. After sacrifice of

mice, colon length, histopathology of the intestinal wall and the

morphological changes were examined by light microscopy.

Anti-oxidant status was investigated by measuring superoxide

dismutase, lipidperoxidation, catalaseandnitricoxideactivities.

Gene expression studies were carried out to analyze the gene

expression of IL-6, IFN-γ and TNF-α. It was observed that the

oral administration of AKBA (5mg/100gm body weight) for

7 days, exhibited potential amelioration of symptoms in DSS

treated mice, resulting in the decrease in inflammation and

soreness when compared to only DSS fedmicewhich displayed

significant decrease in body weight. Overall results indicated

that the AKBA treatment attributed to a collection of activities

including anti-inflammatory, anti-apoptosis and anti-oxidative

effects. Hence, AKBAand its analoguesmaybeadvantageous as

an alternate of non-steroidal anti-inflammatory drugs (NSAIDs)

to manage inflammatory responses with milder side effects

against induced colitis.