gastro-congress-2018-posters-abstracts

allied

academies

Page 57

Note:

Journal of Gastronenterology and Digestive Diseases

Volume 3

J u n e 2 5 - 2 6 , 2 0 1 8 | D u b l i n , I r e l a n d

GASTROENTEROLOGY

International Conference on

HEPATITIS E VIRUS INFECTION: AN UNDERESTIMATED

EVOLVING PROBLEM

Fatma Amer

and

Ergenekon Karagoz

Zagazig University School of Medicine, Egypt

epatitis E virus (HEV) is one of the human hepatitis viruses (family Hepeviridae). This family includes: Orthohepevirus (A-D

species), which infects terrestrial vertebrates, and Piscihepevirus, which infects fish. Orthohepevirus A contains the HEV

variants infecting humans. Eight genotypes are recognized within Orthohepevirus A; 1- 7. It is estimated that 71% of the world

population, are infected with HEV, and the infection results in approximately 3 million symptomatic acute cases and 70000 deaths

annually. The disease predominantly affects young adults. The incubation period ranges from 15-60 days. The course of infection

has 2 phases, the prodromal phase which is usually of short duration and the icteric-phase which lasts days to several weeks. In

nonendemic (autochthonous) type of acute HEV infection, most patients have subclinical manifestations and mild symptoms,

especially inwomen and young persons. Autochthonous hepatitis E has a striking spectrumof serious complications. For unknown

reasons, is predominantly severe and can progress to hepatic failure in pregnant women. Individuals could be infected with HEV

genotypes 1 and 2 from drinking contaminated water. Specifically, HEV genotype three is zoonotic in developed countries. HEV

genotype four infections could be detected in both human and swine in Eastern Asia and Europe. In developed countries, some

cases of vertical transmissions of HEV have been reported as well as in homosexual men. The laboratory diagnosis of HEV

infection depends on the detection of HEV antigen, HEV RNA, and serum antibodies against HEV (immunoglobulin [Ig]A, IgM,

and IgG). Besides improved personal hygiene, sanitation and health education, vaccination might play a crucial role in the future

prevention and control of HEV infection. Chinese vaccine HEV 239 vaccine, which contains truncated HEV capsid protein was

approved in China by the State Food and Drug Administration in January 2012.

J Gastroenterol Dig Dis 2018, Volume 3