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Journal of Gastronenterology and Digestive Diseases
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Volume 3
J u n e 2 5 - 2 6 , 2 0 1 8 | D u b l i n , I r e l a n d
GASTROENTEROLOGY
International Conference on
BCL-G IS A NOVEL PROTEIN OF BAX
Faris Qalenzi
Prince Sattam bin Abdulaziz University, Saudi Arabia
Background & Objective:
BCL-G is a novel protein of Bax (BCL-G associated protein X) inducing caspase-mediated apoptosis.
These proteins are involved in regulating apoptosis both in normal, and in neoplastic cells although their cellular and tissue
distribution is currently unknown. Accordingly, the objective of the current study was to ascertain and define the pattern of
distribution and expression of BCL-G in normal and malignant gastrointestinal human tissues.
Methods:
Using a rabbit monoclonal antibody against BCL-G, the distribution and expression of BCL-G was assessed by
immunohistochemistry in formalin-fixed, paraffin-embedded, benign and malignant human tissues
Results:
We found a variable pattern of positive expression of BCL-G within all the tissues we studied. BCL-G expression was
typically localized in the cytoplasmic paranuclear granules in the epithelial cells in most organs we examined. The intensity of
BCL-G staining related to the maturation state in benign tissue.
Conclusion:
We have demonstrated that BCL-G exhibits a specific distribution pattern that appears to correlate with cellular
differentiation. However, while these distribution patterns are complex they do give a tantalizing insight into function, and
consequently need further investigation to determine their physiological/pathological significance.
fqalenzi@ksu.edu.saJ Gastroenterol Dig Dis 2018, Volume 3