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Journal of Gastronenterology and Digestive Diseases
|
Volume 3
J u n e 2 5 - 2 6 , 2 0 1 8 | D u b l i n , I r e l a n d
GASTROENTEROLOGY
International Conference on
PANCREATIC INNERVATIONS IN HUMAN FETUS: AN
OBSERVATIONAL STUDY
Aritra Banerjee
AIIMS, India
I
n the developing human pancreas, the cholinergic neurons are distributed singly or in the form of ganglia in the inter lobular
connective tissue from 14WG and in the intra lobular connective tissue from 16WG onward. From 25–27 WG onward the typical
adult type isletswere observed. The aimof the studywas to document themorphological changes of neurons and ganglia of human
foetal pancreas at various gestational ages. The present study was performed on human foetuses (n=13) of different gestational
ages. The sample collection was started after getting ethical permission from the Human Ethical Clearance Committee of AIIMS,
New Delhi. Pancreatic tissue samples (Head, body and tail) from aborted foetuses aged 13– 40 weeks of gestation(WG) were
processed. The neurons were studied by using NADPH-d and ChAT for enzyme histochemistry and immunohistochemistry. With
increasing gestational age, the number of neurons in human foetal pancreas was appeared to be reduced in the head, body and
tail of the pancreas and the ganglions were skewed towards the tail. The neurons were mainly surrounding the islets. Numerical
density of cholinergic neural tissue is more in tail than body than head whereas, the nitrergic neuronal tissue is more in head
than body than tail in human foetal pancreas. The knowledge from this study may help in understanding the pathophysiology of
various congenital disorders, relationship between the growth of neurons and islets cells in development of type 1 DM and pain
due to pancreatitis.
aritra.aiims@gmail.comJ Gastroenterol Dig Dis 2018, Volume 3