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Ophthalmol Case Rep 2017 Volume 1 Issue 1
August 21-23, 2017 | Toronto, Canada
EYE AND VISION
3
rd
International Conference on
Aim:
The study was intended to develop a non-aqueous
gel based carrier system of drug aceclofenac (ACE) for its
effective ocular delivery at the inflammatory sites.
Summary of the Problem:
In the treatment of inflammatory
conditions prevailing in eye, multiple strategies have been
employed like steroids and non-steroidal anti-inflammatory
agents. But their use is restricted due to their drawbacks like
low drug permeation and retention, low drug availability,
local irritation and stinging effect at the affected site in the
eye.
Methodology & Theoretical Orientation:
The chosen drug
(ACE) was entrapped in a proniosomal system, which consists
of span 60, cholesterol, maltodextrin and non-aqueous gel
as the secondary vehicle.
Observations:
The particle size, polydispersity index
(PDI) and zeta potential of the prepared system were
obtained as 369.6 nm, 0.513 and -25.3 mV, respectively.
FTIR studies proved the useful interaction of the drug with
the bilayers of the proniosomal system. The prepared gel
system was a shear-thinning in nature with the yield value
of 12.31 and viscosity of 173.29. Anti-inflammatory and
analgesic animal models revealed the supremacy of the
prepared formulations over the marketed formulations
with increased ocular bioavailability of the drug at the site
of eye inflammation. Ocular irritancy studies performed on
rabbit eye model proved the safety and non-irritancy of the
prepared formulation. Moreover, the formulation was found
stable for the period of six months.
Conclusion:
The current findings provide the lead for the
development of an effective ocular formulation of ACE with
substantial stability in the proniosomal system.
Speaker Biography
Supriya Verma has been engaged in experimental laboratory work that includes
formulation development,
in vitro
characterization and
in vivo
evaluation of the novel
drug delivery based formulations
i.e.,
liposomes, niosomes, solid lipid nanoparticles,
nanostructured lipid carriers, etc. Her area of research is based on systematic design
and development of nanostructured delivery system of Aceclofenac and Risedronate.
In the last four years of research experience, she has got wonderful exposure on topical
and oral drug delivery systems in an industry (Panacea Biotech, Lalru) as well as in an
academic institute (University Institute of Pharmaceutical Sciences, Panjab University,
Chandigarh). She has not only involved in research but also undertaking teaching of
Undergraduate and Postgraduate classes. Moreover, she is having collaboration with
medical institutes
i.e.,
PGIMER, Chandigarh and AIIMS, New Delhi for the assistance
of clinical studies over there. Also she is writing research articles and book chapters
related to her professional domain. She has attended various National as well as
International level conferences and been awarded with five best paper awards in the
last four years.
e:
supriya_punjab@yahoo.comNon-aqueous gel based carrier system for the ocular delivery of aceclofenac with enhanced efficacy,
safety and stability
Supriya Verma, Bhupinder Singh
and
O P Katare
Punjab University, India