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Journal of Industrial and Environmental Chemistry
|
Volume 2
GREEN CHEMISTRY &
TECHNOLOGY
7
th
International Conference on
J u n e 1 8 - 2 0 , 2 0 1 8 | D u b l i n , I r e l a n d
Bryan Li, J Ind Environ Chem 2018, Volume 2 | DOI: 10.4066/2591-7331-C1-002
CONTINUOUS GENERATION
OF ANHYDROUS
tert
-BUTYL
HYDROPEROXIDE AND ITS
APPLICATION IN FLOW OXIDATION
Bryan Li
Pfizer Worldwide Research and Development, USA
A
nhydrous
tert
-Butyl hydroperoxide (TBHP) is a powerful oxidizing
agent in many chemical transformations. Despite the versatility in
organic reactions, the use of anhydrousTBHP has been greatly limited due
to safety concerns of its shipping, handling, and storage and particularly
on the production scale. Herein, we describe a membrane pervaporation
method that allows the production of anhydrous TBHP solution in
continuous manner. The system consists of membrane modules in series
those are made of perfluorinated polymer with very high gas permeability
allowing it to remove water efficiently. The pervaporation skid has been
successfully implemented in the production by continuously generating
anhydrous 1.5 M TBHP solution in nonane up to 100 mL/min for more
than 96 hours achieving the target of 0.15 wt% of water. An integrated
continuous flow oxidation of a
γ
-butyrolactam produces 100+ kg of a
pharmaceutical intermediate.
Bryan Li is currently a Research Fellow in the
Chemical R & D of Pharmaceutical Science
Small Molecule division, Pfizer Inc., Groton,
Connecticut, USA. He received his BSc. from
Eastern University of Science & Technology,
Shanghai, China in 1986, and PhD. in 1993 from
University of Rhode Island, USA under the guid-
ance of Prof. Elie Abushanab. Subsequently,
he worked in Prof. Gary Posner’s group at the
Johns Hopkins University at Baltimore, Mary-
land as a postdoctoral fellow for two years. In
1998, he joined Pfizer as a process chemist,
and serves as a program lead responsible for
exploratory development of drug candidates. In
addition, Li has been leading and driving the de-
velopment and implementation of continuous
flow processes in the production in Pfizer.
Bryan.li@pfizer.comBIOGRAPHY