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March 07-08, 2019 | London, UK

Journal of Diabetology | Volume 3

Annual Summit on

Diabetes, Obesity & Heart

Diabetes, Endocrinology and Metabolic Syndrome

International Conference on

Joint Event

Notes:

Investigation of aldose reductase inhibitory and anti-hyperglycemic potential of 2, 4-thiazolidinedione

derivatives and evaluation of their protective effect against galactose induced and STZ diabetic

cataract in rats.

Chirag Prajapati

APMC College of Pharmaceutical Education & Research, India

ataract is viewed as a major cause of visual impairment

in diabetic patients as the incidence and progression

of cataract is elevated in patients with diabetes mellitus.

This is the reason for highly required biochemical solutions

or pharmacological intervention that will maintain the

transparency of the lens and delay the progression of cataract.

Polyol pathway has been implicated as a major contributor

in the pathogenesis of diabetic cataract along with chronic

hyperglycemia as the root cause. Male SD rats were selected

for this study. In the present study, we have investigated

the novel effect 2, 4- thiazolidinedione derivatives that have

potential to inhibit the aldose reductase enzyme and to act as

a ligand of PPAR-γ against galactose-induced and single dose

(55 mg/kg i.e.) of streptozotocin induced diabetic cataract in

rats. All the above models of cataract showed development of

mature cataract in the disease control group at the end of the

respective study. Levels of aldose reductase, polyols, sodium,

calcium and malondialdehyde in the lens had significantly

elevated whereas antioxidant enzymes, total proteins, soluble

proteins and potassium levels had significantly decreased

in disease control rats as compared to the age-matched

control rats, this indicates the accelerated polyol pathway

and associated oxidative stress in lens. The treatment with

Compound A (80 and 200 mg/kg, p.o.) and compound B (80

and 200 mg/kg, p.o.) significantly ameliorated the alterations

in polyol pathway and oxidative stress with clear delay in the

onset and progression of cataract. Results of the present study

suggest the potential of these compounds as pharmacological

intervention against diabetic cataract.