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March 07-08, 2019 | London, UK
Journal of Diabetology | Volume 3
Annual Summit on
Diabetes, Obesity & Heart
Diabetes, Endocrinology and Metabolic Syndrome
International Conference on
Joint Event
&
The possible role of diabetes in the etiology of Laryngeal Cancer
Roberto Menicagli
1
and
Ortensio Marotta
2
1
Roma Biomed Research, Italy
2
Naples University, Italy
L
aryngeal cancer and oral cancer are not always correlated
with genetic mutations, HPV infection, smoking, and
alcohol abuse. In the absence of these risk factors, there is an
increase on these cancers with a parallel increase of diabetes.
The aim of this study is to verify if diabetes could be a risk
factor for the laryngeal cancer. A questionnaire was given to
a group of ninety laryngectomees to verify if these patients
have presented diabetes and xerostomia before surgery. In
two groups, diabetics and healthy persons, the values of the
salivary mucins and the pH were evaluated. The results were
statistically analysed using Fisher Exact Test and Chi square
Test. Diabetes is a risk factor: p= 0.0445 for laryngectomees
male vs control group. Xerostomia in laryngectomees male is
a risk factor: p= 0.050. The values of mucins and pH in diabetic
group show significant difference: p=0.05 vs control group.
In all autoimmune diseases, a decrease in the value of pH and
salivary flow consequently decreases the value of spinnbarkeit
which measures the capacity of the mucous layer to adhere to
the epithelium and alter the protective oral mucin layer. We
find that diabetes is epidemiologically correlatedwith laryngeal
cancer. In fact, only diabetes increases the concentration of
salivary mucins with a formation of mucin layer even more
reduced, and so completely ineffective in protecting the
mucosa.
e:
menicagli@libero.it