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J Pharmacol Ther Res 2017 Volume 1 Issue 2
November 02-03, 2017 Chicago, USA
4
th
International Congress on
International Conference and Exhibition on
Drug Discovery, Designing and Development
Biochemistry, Molecular Biology: R&D
&
Free radicals production in rat’s gastric mucosa during chronic nitrate intoxication
Akimov O Ye
Ukrainian Medical Stomatological Academy, Ukraine
N
itrate intoxication is a serious problem both in Ukraine
and in USA. In Ukraine the predominant source of nitrate
intoxication is groundwater. That is especially true to regions
which are mostly agricultural such as Poltava, Kirovograd, and
Nikolayev regions. In USA similar problems arise in Oklahoma,
Kansas, Nebraska, Iowa and several other states. Groundwater
is not the only source of excessive nitrate intake. Recent trend
in creation of nitric oxide (NO) releasing medications can lead
to chronic nitrate intoxication in regions where nitrates are
abundant in groundwater. Nitrates mostly undergo metabolic
changes in gastrointestinal tract. So stomach is one of the
first organs to suffer from chronic nitrate intoxication. There
are evidences in literature indicating that nitrates can shift
NO production. Most scientists tend to blame nitrate-nitrite
reduction for the changes. However there is clearly not enough
information about functioning of nitrate-nitrite reductases. The
superoxide anion radical (•O
2
-) production also changes during
nitrate intoxication. Since •O2- is one of the most common
reasons of cell injury and death increase in its production may
lead to tissue damage. Functioning of superoxide dismutase
(SOD) may also change during nitrate intoxication providing
even more risks to tissues.
In this seminar, I will discuss the changes in production of NO
and •O
2
- during chronic nitrate intoxication in gastric mucosa
of rats.
Speaker Biography
Akimov Oleh Yeugenovich is a PhD student in HSEEU “Ukrainian medical stomatological
academy”, department of Pathophysiology. Graduated from the Faculty of Dentistry
of the HSEEU “Ukrainian Medical Stomatological Academy” in 2009. Works at the
department since 2015. PhD thesis theme: “Mechanisms metabolic disorders in
gastric mucosa of rats under conditions of combined excess intake of sodium nitrate
and sodium fluoride and their correction by enterosorbents”. He is the author of over
20 scientific works and 3 patents for utility models
e:
riseofrevan5@gmail.com