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J Pharmacol Ther Res 2017 Volume 1 Issue 2
November 02-03, 2017 Chicago, USA
4
th
International Congress on
International Conference and Exhibition on
Drug Discovery, Designing and Development
Biochemistry, Molecular Biology: R&D
&
Chemical composition, antioxidant and antibacterial activity of
Thuja orientalis
essential oil
Wajaht A Shah
and
Mahpara Qadir
University of Kashmir, India
E
ssential oils derived from many aromatic plants are well
known to possess cytotoxic, antioxidant, antifungal,
insecticidal and antimicrobial activities. This work was
carried out to evaluate chemical composition, antioxidant
and antibacterial activity of
Thuja orientalis
essential oil.
Thuja orientalis
(family:
Cupressaceae
) is widely cultivated as
a common ornamental plant. It possesses anti-plasmodial,
antioxidant and elastase inhibitory activities. Chemical
composition and pharmacological potential of hydro distillate
from
Thuja orientalis
are reported in this study. Fresh fruitswere
subjected to conventional hydrodistillation. Antioxidant activity
was assessed as free radical scavenging capacity (RSC) towards
2, 2-diphenyl-1-picrylhydrazil (DPPH) radicals and antibacterial
activity was evaluated against six test bacteria by agar well
diffusion method. Qualitative and quantitative analysis of
Thuja orientalis
hydrodistillate by gas chromatography coupled
with mass spectrometry revealed the presence of nineteen
constituents, representing 94.6% of the total oil. The major
constituents of oil were alpha-pinene (83%), sabinene (2.6%),
delta-3-carene (2.5%). The oil showed appreciable antibacterial
effect against all Gram-positive and Gram-negative bacteria
tested with MIC values between 12.8-25.6 μg/ml. Therefore
this oil could be used in the formulation of antimicrobial and
antioxidant agents.
e:
shahwajaht@yahoo.com