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J Pharmacol Ther Res 2017 Volume 1 Issue 2
November 02-03, 2017 Chicago, USA
4
th
International Congress on
International Conference and Exhibition on
Drug Discovery, Designing and Development
Biochemistry, Molecular Biology: R&D
&
Synthesis and cytotoxic activity screening of novel piperazinyl pyrimidine derivatives
Meric Koksal
1
, Tugce Ozyazici
1
, Ece Gürdal
1
, Mine Yarım
1
, Eren Demirpolat
2
and
M Betul Yerer Aycan
2
1
Yeditepe University, Turkey
2
Erciyes University, Turkey
T
he discovery of potent, selective and less toxic anticancer
compounds is an important goal for researchers
in the field of Medicinal Chemistry. In recent years,
several pyrimidine derivatives have been involved in the
structure of many compounds which have been used as
chemotherapeutic agents and they have used in wide clinical
applications. In this study, a group of novels 6-phenyl-3-
[2-(substituted piperazinyl) ethyl] hexahydropyrimidine-
2,4-dione derivatives to observe the desired anticancer
activity due to pyrimidine and piperazine based scaffolds.
Synthesized compounds purity was determined with thin
layer chromatography and their molecular structures
were lightened with FT-IR,
1
H NMR,
13
C NMR and mass
spectroscopic techniques.
e:
merickoksal@yeditepe.edu.tr