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J Nutr Hum Health 2017 Volume 1 Issue 2
Notes:
July 24-26, 2017 | Vancouver, Canada
International conference on
DIABETES, NUTRITION, METABOLISM & MEDICARE
N
europathies in type 2 diabetes mellitus (T2DM) patients
are well documented. However, electrophysiological
changes in their peripheral nerves, particularly before
overt peripheral neuropathy have received much less
attention. Hence, we studied electrophysiological status of
bilateral sural nerves in T2DM patients who do not show
clinical evidence of peripheral neuropathy. We selected
35 male patients with T2DM and 35 age- and sex-matched
healthy controls without any clinical evidence of peripheral
neuropathy and other infectious, systemic, metabolic, and
neuropsychiatric illnesses after informed written consent.
Nerve conduction study of bilateral sural nerves of both
the groups was performed at lab temperature of 26±2ºC
by antidromic method of stimulation. Latency, conduction
velocity, amplitude, and duration of sural sensory nerve
action potential (SNAP) were measured. In our study, we
found reduced amplitudes of bilateral sural SNAP in T2DM
patients compared to the controls [left (12.46 ± 3.77) μV vs.
(16.42 ± 4.58) μV, p=0.000; right (11.96 ± 4.45) μV vs. (16.62
± 6.20) μV, p=0.001] though they were above the normal
cut-off value of ≥4 μV. Durations of bilateral sural SNAP were
prolonged in T2DM patients compared to the controls [left
(1.99 ± 0.38) ms vs. (1.67 ± 0.27) ms, p=0.000; right (1.92 ±
0.47) ms vs. (1.55 ± 0.33) ms, p=0.000]. Reduced amplitude
of sural SNAP suggests axonal loss, whereas prolonged
sural SNAP duration is seen in polyneuropathies. Hence, we
concluded that electrophysiological alterations suggestive
of peripheral neuropathy occur in T2DM patients before
overt peripheral neuropathy. Early detection of peripheral
neuropathy in T2DM patients helps to prevent long-term
complications of diabetes mellitus such as foot ulcers and
amputations.
Biography
Raju Panta earned professional medical degrees of MBBS and MD in Basic and Clinical
Physiology, from the nationally and internationally accredited medical colleges
in Nepal. He was awarded with a “Certificate of Expertise in Electrophysiology”
after completion of his doctorate thesis during his residency. His thoughtful ideas
inspired him to accomplish research work on Diabetes Mellitus, where he studied
electrophysiological evidences of peripheral and central neuropathies in type 2
diabetes mellitus patients before they develop features of peripheral neuropathy.
Working as a faculty of Physiology at Trinity School of Medicine, St. Vincent and the
Grenadines. He has demonstrated excellence in teaching as evidenced by four “SGA
awards” in recognition of best professor. His organizational memberships include the
American Physiological Society, International Association of Medical Science Educators,
Association for Medical Education in Europe, Physiological Society of Nepal, and Nepal
Medical Council..
tsomdesk.rp@gmail.comElectrophysiological status of sural nerve in type 2 diabetic patients before overt peripheral neuropathy
Raju Panta
1
, Bishnu Hari Paudel
2
and
Dilip Thakur
2
1
Trinity School of Medicine, St. Vincent and the Grenadines
2
B P Koirala Institute of Health Sciences, Nepal