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J Nutr Hum Health 2017 Volume 1 Issue 2
July 24-26, 2017 | Vancouver, Canada
International conference on
DIABETES, NUTRITION, METABOLISM & MEDICARE
Background & Objectives:
Chemerin is believed to be a
mediator for the adipose tissue inflammation that occurs
in obesity. The present study compared chemerin levels
between healthy and type 2 diabetic women matched for
age and body composition. We also aimed to assess the
relationship of serumchemerin levelswith body composition,
insulin resistance, dyslipidemia and glycemic control.
Material and Methods:
This observational case control
study was conducted at the Departments of Physiology and
Medicine, Saud University Riyadh, Saudi Arabia. A total of 100
subjects were recruited, including 51 adult diabetic females,
and a control group consisting of 49 healthy females. Finally
80 subjects were selected as per inclusion criteria. In the
finally selected group, 45 of were type 2 diabetics and 35
were healthy subjects matched for age, body mass index
(BMI) and body composition with age ranging between 30-
65 years. Body composition analysis was estimated using
bioelectrical impendence analyzer. Fasting venous blood
samples were analyzed for glycemic markers, lipids and
chemerin. Insulin resistance and sensitivity indices were
calculated by HOMA-IR and QUICKI using standard formulas
Results:
The two groups were matched for age, BMI, body
fat percentage (BF%), basal metabolic rate (BMR), truncal
fat and waist hip ratio (WHR). Serum chemerin levels were
higher in diabetics than controls (p=0.001). Systolic blood
pressure, weight, fat mass and visceral fat were found to be
significantly higher in diabetics when compared to controls.
Fasting blood glucose (FBG), glycocylated hemoglobin
(HbA1c), low density lipoprotein (LDL), triglycerides
(TG), insulin and HOMA-IR were significantly higher in
diabetics compared to controls. While QUICKI and HDL
were significantly lower in diabetics compared to controls.
Chemerin levels correlated positively with age (r=.300,
p=0.007), waist hip ratio (r=0.250, p=0.026), weight(r=0.270,
p=0.016), BMI (r=0.334, p=0.003), BF%(r=0.325, p=0.003), fat
mass(r=0.250, p=0.026), visceral fat (r=0.356, p=0.001) and
truncal fat mass and truncal fat %, serum basal insulin levels
and HOMA IR, while it correlated inversely with QUICKI. In
multiple linear regression analysis age (r=0.236, p=0.023),
BF% (r=0.265, p=0.014) and basal insulin levels (r=0.265,
p=0.014) were independent predictors of chemerin.
Conclusions:
Serum chemerin levels are elevated in patients
with type 2 DM compared to healthy control subjects and are
positively correlated with adiposity and Insulin resistance in
patients with type 2 DM.
shahidhabib44@hotmail.comSerum chemerin relationships with body composition, insulin resistance, dyslipidemia and glycemic
control in Saudi women
Ashraf Husain and Syed Shahid Habib
Department of Physiology, College of Medicine & King Saud University Hospitals
King Saud University, Riyadh