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Journal of Pharmacology and Therapeutic Research
Volume 1 Issue 1 Clinical Pharmacy 2017
Notes:
Page 47
December 07-09, 2017 | Rome, Italy
7th World Congress on
Clinical Pharmacy and Pharmacy Practice
Pharmacotherapy assessment of patients in
isolation precautions: A new experience at a
university hospital
Patricia Moriel, Karen Prado Herzer Mattos, Cinthia Madeira de
Souza and Isabela Romão Gouvêa
University of Campinas, Brazil
Introduction: Since the pharmacotherapy assessment
is not implemented in clinical practice in most Brazilian
hospitals, every specialist that participates in the care
process of a patient can include a new drug in the
pharmacotherapy, not taking into consideration the
potential drug-drug interaction.
Objectives: This study aim to evaluate the
pharmacotherapy of patients in isolation precaution
focusing on drug-drug interactions, risks of toxicity and
clinical outcomes.
Methods: Evaluation of medical prescription of patients in
isolation precautions between September 2015 and May
2016 at general adult intensive care unit and specialized
wards of a University Hospital. To identify the potential
drug-drug interactions it was used the Micromedex®
database. Antibiograms of every patient were followed
throughout the antimicrobial treatment to evaluate the
clinical outcomes.
Results: Prescriptions of 185 patients were analyzed and
100.0% of them were associated with at least one drug-
related problem. Data demonstrated a high prevalence of
contraindicated and major potential drug-drug interaction
among the medical prescriptions evaluated. The most
frequent were the interactions involving fluconazole,
amiodarone, fentanyl and midazolam.
Conclusion: This study demonstrates a high prevalence
of potential drug-drug interaction resulting from the
complexity of pharmacotherapy of patients requiring
contact precautions. Nevertheless, drug-drug interactions
are among the main evitable causes of adverse drug
reaction once the medical prescription assessment is a
simple way by which pharmacists can early detect the
drug interactions to prevent them from occurring. Specially
regarding to antimicrobials, a microbiological diagnosis
is quite useful in narrowing the regimen and ensure an
accurate and satisfactory treatment.
Biography
Patricia Moriel is a Full Professor in the Faculty of Pharmaceutical Science
at State University of Campinas (UNICAMP), Brazil. She is a Leader of the
Clinical Pharmacy Group that is involved in the study of pharmacotherapy, drug
adverse events, pharmacovigilance, pharmacokinetic, pharmacogenomics
influences in adverse events, especially in cancer. She has authored more
than 45 research articles, awards, conferences and the granting of a research
projects. She has been the director of several works of Master in Medical and
Pharmaceutical Science and Doctoral theses.
Patricia Moriel et al., J Pharmacol Ther Res 2017