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Journal of Pharmacology and Therapeutic Research
Volume 1 Issue 1
Clinical Pharmacy 2017
Notes:
Page 42
December 07-09, 2017 | Rome, Italy
7
th
World Congress on
Clinical Pharmacy and Pharmacy Practice
Comparison between dinoprostone (PGE2)
vaginal gel and PGE2 vaginal tablet for the
induction of labour, in term primigravida
pregnant women at Women’s Hospital-Qatar,
a retrospective study
Abdallah Kamal, Mouza Al-Hail, Muna Al-Saadi, Mahmoud Gassim
and
Ahmad Morsi
Women’s Hospital, Hamad Medical Corporation, Qatar
Objective:
To compare the effectiveness of PGE2 vaginal
gel vs tablet for the induction of labour in primigravida
women at term.
Design:
A retrospective study conducted on patients who
received PGE2 between 1 May and 31 October 2015.
Setting:
The induction unit/Women Hospital-Qatar.
Main Outcome Measures:
To assess the rate of
successful vaginal delivery achieved following induction
of labour in primigravida induced with PGE2 vaginal tablet
compared to gel. In addition to identify the proportion of
women delivered vaginally within 24 hours of receiving
PGE2 tablet compared to gel.
Results:
63 women received PGE2 gel vs 67 women
received tablet. There was insignificant difference between
both groups in the percentage of vaginal delivery (70.1%
in gel vs 57.1% in tablet, p= 0.123), and insignificant
difference in vaginal deliveries within 24 hours (45.7% in
gel vs 54.3 % in tablet, p = 0.55). However, a significant
difference found when comparing mean time between
the first induction dose and vaginal delivery specifically in
patients delivered vaginally within 24 hours (771.76 min
± 341.2 in gel vs 989.52 min ± 275.7 in tablet group, p =
0.02). We also found that all patients achieved cesarean
section delivery in both groups required epidural medicine
for pain relief (p<0.001).
Conclusions:
Overall, there were no significant
differences in the rate of successful vaginal delivery as
well as vaginal delivery within 24 hours between PGE2
vaginal gel and tablet. However, in patients who delivered
vaginally within 24 hours, patients receiving vaginal
gel showed faster induction to vaginal delivery when
compared to tablet.
Biography
Abdallah Kamal, has completed MSc degree in clinical pharmacy from Queens
University Belfast/UK in November 2016, working currently as a clinical
pharmacist at Women’s Hospital/Hamad Medical Corporation/Doha/Qatar
amahmoud11@hamad.qaAbdallah Kamal et al., J Pharmacol Ther Res 2017