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June 12-13, 2019 | Edinburgh, Scotland
Pediatrics and Clinical Pediatrics
2nd World Congress on
Current Pediatric Research | Volume: 23
Granulocyte colony stimulating factor in improving outcomes of Neonatal Sepsis: A
meta-analysis
Grazielle V, Mary Mae Catherine Y, Kathlynne Anne A S and Maria Isabel Q
Philippine General Hospital, Philippin
Background : Neonatal sepsis complicatedwith neutropenia
increases risk of mortality by 50%. The immature neutrophil
production of neonates is often overwhelmed by severe
infection. Granulocyte colony stimulating factor (G-CSF),
a naturally occurring cytokine used to support neutrophil
recovery during chemotherapy, is a possible treatment that
can improve outcomes of neonatal sepsis.
Objectives: To determine the efficacy of G-CSF in
decreasing mortality and morbidity in septic neonates.
Methodology: Electronic searches were conducted on
online journal databases. Unpublished or ongoing studies
were sought in training institutions accredited by the
Philippine Pediatric Society. The investigators included
randomized control trials using G-CSF on neonates with
proven or suspected sepsis.
Results: Twenty-two trials were identified and thirteen were
assessed to be eligible for review. The studies had a total of
530 participants, with the largest having 78 subjects. Relative
risks (RR), mean differences (MD) and standard mean
differences (SMD) with 95% confidence intervals (CI) using the
fixed effect model and randomeffects model were reported in
the results. There was a significant decrease in mortality (RR
0.69, 95%CI 0.48 to 0.99) with a greater reduction of mortality
rates for preterm neonates, neonates with low birthweight
and neonates who had baseline neutropenia. There was no
significant reduction of morbidities caused by neonatal sepsis.
Conclusions : There is moderate quality evidence which
suggests that G-CSF as an adjunct treatment for neonatal
sepsis significantly decreases mortality with greater
benefit to preterm neonates, those with low birthweight
and those with baseline neutropenia. The studies did not
show any benefit in reducing sepsis-related morbidity.
e:
Current Pediatric Research, Volume 23
ISSN: 0971-9032