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Journal of Biotechnology and Phytochemistry
Volume 1 Issue 3
Chemistry World 2017
Page 60
November 13-15, 2017 Athens, Greece
7
th
World Congress on
Chemistry
Cu(II) complexes of hydrazone Schiff base
ligands: synthesis, characterization, DNA and
topoisomerase i enzyme interactions
Ramazan Gup, Elif Eda Şengül
and
Cansu Gokce Topkaya
Mugla Sitki Kocman University, Turkey
Small inorganic complexes that can interact with DNA or
other biological molecules have tremendous conservation.
Because such compounds can pass the inhibitions that large
molecules cannot pass through to show desired activities. It is
a known phenomenon that transitionmetal complexes oxidize
or bind to DNA in the presence or absence of reductants.
Therefore, it is important to understand the structure activity
relationship especially in the antitumor action mechanism of
metal complexes that can bind to DNA under physiological
conditions and specifically cleave DNA. In particular, Cu(II)
complexes containing Schiff base are much more attractive
as they can enter into the bases of DNA. The interaction of
DNA with metal complexes is closely related to the design
of synthetic restorative enzymes and chemotherapeutic
drugs. Transitional metal complexes play a key role in the
formation of newly bound complexes in the DNA domain,
although structural flexibility and variable dimensionality are
taken into consideration. In recent years, the use of certain
chemotherapy drugs by interfering with topoisomerases in
cancer cells has focused on the enzyme topoisomerase I in the
development of anticancer drugs. In this study, new cationic
hydrazone Schiff bases and their coordination compounds
with Cu(II) have been synthesized and characterized. Firstly,
various p-substituted benzohydrazine derivatives were reacted
with cationic acetophenone derivatives, which were served
as a chelating bridge, in order to prepare hydrazone Schiff
base ligands. In the second step of this study, coordination
compounds of the synthesized ligands with biologically
important transition metal Cu(II) were isolated and
characterized. Then, inhibitory activities of topoisomerase
I enzyme and DNA binding and cleavage activities was
examined for the compounds. The effect of the factors such
as ligand and geometry tetrahedral square-planar, octahedral,
etc. on the activity where be defined. That the synthesis of
some Schiff base derivatives bearing functional groups such
as -OH and -NH
2
increasing the pharmacological activities
was discussed in this study. Consequently, novel and effective
agents interacting with DNA, showing topoisomerase
inhibitions activity have been revealed.
rgup@mu.edu.trJ Biotech and Phyto 2017