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May 13-14, 2019 | Prague, Czech Republic
Chemistry and Medicinal Chemistry
9th World Congress on
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 9 ISSN: 2249-622X
Material science for medical radionuclides production: Cyclotron solid target
preparation in the framework of LARAMED project
Hanna Skliarova, S Cisternino, G Cicoria, M Marengo, G Gorgoni, E Cazzola, J Esposito, C Rossi Alvarez and
V Palmieri
National Institute of Nuclear Physics, Italy
Nuclear medicine is a field of medicine that uses
a trace amount of radiopharmaceuticals for the
diagnosis and treatment of many health conditions such
as certain types of cancer, neurological and heart diseases.
Radiopharmaceuticals are pharmaceutical drugs containing
radioisotopes.
Nowadays two main approaches to produce radioisotopes
for medical interest are used: as decay products in so-called
“generators” and a direct production by cyclotron irradiation
of a dedicated target.
At INFN-LNL a new high performance 70 MeV cyclotron has
been installed. It will be dedicated not only to nuclear physics
study, but also part-time to medical physics application.
LARAMED (Laboratory of Radioisotopes for Medicine)
project is aimed to R&D on medical radionuclides cyclotron
production. Waiting for the facility full operation, LARAMED
team has started working on the cyclotron production of
conventional (Tc-99m) and emerging (Cu-67, Sc-47, Mn-52)
radionuclides in a collaboration with other institutions.
Suitable target design and preparation is one of the most
critical technological challenges in cyclotron production
of radioisotopes. To maximize the nuclear reaction yield,
the production should be performed at maximum proton
currents. Thus, the target system should provide high
efficiency of heat dissipation. The basic solid target system
supposed to be the target material deposited on a baking
plate, liquid/gas cooled. In order to maximize the heat
dissipation, the target should be constructed of materials
with maximum thermal conductivity, including both target
material itself and target backing plate, by a method
providing good thermo-mechanical contact between them.
The chemical inertness of the backing plate in the target
dissolution conditions should be also considered.
For different radionuclides production LARAMED group
has studied a set of non-classical techniques for metallic
target preparation, like magnetron sputtering, High energy
Vibration Powders Plating (HIVIPP) and Spark Plasma
Sintering (SPS). Current presentation will include results on
the use of described methods.
e:
Asian J Biomed Pharmaceut Sci, Volume:9
DOI: 10.4066/2249-622X-C2-021