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May 13-14, 2019 | Prague, Czech Republic
Chemistry and Medicinal Chemistry
9th World Congress on
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 9 ISSN: 2249-622X
Design and Synthesis of Cyclometalated Iridium (III) Complex-Peptide Hybrids for
the induction of Cancer Cell Death
Shin Aoki
Tokyo University of Science, Japan
Cyclometalated iridium (III) complexes such as fac-
Ir(tpy)3 (tpy = 2-(4’-tolylpyridine) are strong triplet
luminescent organometallics not only in the production
of organic light-emitting diodes (OLED) but also as
chemosensors and bioimaging agents, due to their
excellent photophysical properties and stability even in
aqueous solution [1]. In this paper, we present the design
and synthesis of new cyclometalated Ir complex-peptide
hybrids (IPHs) as detectors of cancer cells and/or inducers
of their cell death [1,2] based on the regioselective
substitutions [3]. The IPHs linked with cationic peptides
such as GGKK(K) sequences through C6 or C8 linker exhibit
potent cytotoxicity against Jurkat cells and strong green
emission from IPHs were observed in dead cells [2]. On the
other hand, it was found that IPHs having cyclic peptides
that had been reported to bind to death receptor (DR)
of cancer cells bind to DR5 expressed on cancer cells and
induce their necrosis-type [3a] or apoptosis-type cell death
[3b]. In this paper, these results will be reported.
Speaker Biography
Shin Aoki graduated from the University of Tokyo with B. S. (1986), M.S.
(1988), and Ph.D. (1992) degrees in pharmaceutical sciences under
the supervision of Prof. Kenji Koga. He started his academic carrier as
an assistant professor at the University of Tokyo from 1990. Following
postdoctoral positions with Professor Chi-Huey Wong at the Department
of Chemistry, the Scripps Research Institute, USA, he joined Prof. Eiichi
Kimura’s research group in 1995 at the Faculty of Medicine, Hiroshima
University, where he became an associate professor in 2001. In 2003, he
was promoted to a professor at the Faculty of Pharmaceutical Sciences,
Tokyo University of Science, and has been appointed as the Vice Dean
of Research Institute for Science and Engineering, Tokyo University of
Science, since 2018. He is a recipient of the Award of Japan Society of
Coordination Chemistry for Young Scientists (1999), the AJINOMOTO
Award in Synthetic Organic Chemistry, Japan (2001), the Pharmaceutical
Society of Japan Award for Young Scientists (2002), and so on. His
major research interests are organic synthetic chemistry, bioinorganic
chemistry, supramolecular chemistry, photochemistry, and medicinal
chemistry, mainly using metal complexes in aqueous solutions.
e:
Shin Aoki, Asian J Biomed Pharmaceut Sci, Volume:9
DOI: 10.4066/2249-622X-C2-021