cardiology-summit-2019-scientifictracks

Page 42

March 25-26, 2019 | Amsterdam, Netherlands

CARDIOLOGY

AND CARDIAC NURSING

World Congress on

Cardiology Summit 2019

Journal of Cardiovascular Medicine and Therapeutics | Volume 3

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

DIRECT EVIDENCE OF VIRAL INFECTION AND MITOCHONDRIAL ALTER-

ATIONS IN THE BRAIN OF FETUSES AT HIGH RISK FOR SCHIZOPHRENIA

Segundo Mesa Castillo

Psychiatric Hospital of Havana, Cuba

here is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point to-

wards the intra-uterine environmental factor that act specifically during the second pregnancy trimester

producing a direct damage of brain of the fetus. The current available technology does not allow observing what

is happening cellular level since the human brain is not exposed to a direct analysis in that stage of the life in

subjects at high risk of developing schizophrenia.

Methods:

In 1977 we began an direct electron microscopic research of the brain of fetuses at high risk from

schizophrenic mothers in order to finding differences at cellular level in relation to controls.

Results:

In these studies we have observed within the nuclei of neurons the presence of complete and incom-

plete viral particles that reacted in positive form with antibodies to herpes simplex hominis type I [HSV1] virus,

and mitochondria alterations.

Conclusion:

The importance of findings can have practical applications in the prevention of the illness keeping

in mind its direct relation to the aetiology and physiopathology of schizophrenia. A study of gametes or the

amniotic fluid cells in women at risk of having a schizophrenic offspring is considered. Of being observed the

same alterations that those observed previously in the cells of the brain of the studied foetuses, it would intend

to these women in risk of having schizophrenia descendant previous information of the results the voluntary

medical interruption of the pregnancy or an early anti HSV1 viral treatment as preventive measure of the later

development of the illness.

Segundo Mesa Castillo, J Cardiovasc Med Ther 2019, Volume 3

Segundo Mesa Castillo is specialist in neurology, he worked for 10 years in the institute of Neurology of Havana, Cuba.

He has worked in electron microscopic studies on schizophrenia for 32 years. He was awarded with the International

Price of the Stanley Foundation Award Program and for the professional committee to work as a fellowship position in

the Laboratory of the Central Nervous System Studies, National Institute of Neurological Diseases and Stroke under Dr.

Joseph Gibbs for a period of 6 months, National Institute of Health, Bethesda, Maryland, Washington D.C. USA, June 5,

1990. At present he is member of the Scientific Board of the Psychiatric Hospital of Havana and give lectures to residents

in psychiatry.

BIOGRAPHY