biomaterials-materials-physics-2019-keynote

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May 20-21, 2019 | Vienna, Austria
Biomaterials and Nanomaterials &
Materials Physics and Materials Science
2nd International Conference on
Page 45
Journal of Materials Science and Nanotechnology | Volume 3
Rossana Mara da Silva Moreira Thire
University of Rio de Janeiro, Brazil
Towards new strategies for development of bone tissue engineering
composite scaffolds
3D printing techniques become attractive to produce
scaffolds for bone tissue engineering (BTE) with high
complexity, anisotropy and reproducibility, different
shapes and geometries etc. Poly(3-hydroxybutyrate) (PHB)
is a microbial and biodegradable polyester, which has been
studied as raw material to produce scaffolds for BTE. PHB
is biocompatible and has no toxicity to several mammalian
cells lines. Addition of a calcium phosphate phase into
PHB materials should potentially have the dual effect of
improving both the bioactivity and mechanical properties.
The aim of this work was to evaluate a join strategy
to develop a scaffold for BTE applications: one related
to raw materials and other related to manufacturing
technique. PHB/beta-tricalcium phosphate (b-TCP)
composite scaffolds were directly fabricated by 3D mini-
screw extrusion printing. This 3D printing technique uses
a simple device, which allows the direct use of a powder
mix, without the need for prior preparation of solution or
filaments. Compositions containing 0-30 wt.% of b-TCP
were used. Scaffolds with physical integrity, internal pore
structure of 0⁰/90⁰ pattern and compressive modulus
like that of human trabecular bone were produced. No
cytotoxicity was observed for any scaffold. In vitro release
of cytokines and growth factors was monitored for 24
h. Higher concentration of growth factors released was
observed for composite scaffolds. A release of pro- and
anti-inflammatory cytokines was also detected. The use
of scaffolds in critical-size bone defects did not alter any
thermal sensitivity and motor performance of male Wister
rats. Physical and biological tests results showed that PHB
scaffolds containing 20 wt.% of b-TCP has greater potential
for bone tissue engineering application than those of pure
PHB. Moreover, the employed 3D printing technique opens
up the opportunity for the use of a wider range of materials
and thus, is a viable alternative manufacturing process for
composite scaffold materials.
Speaker Biography
Rossana Mara da Silva Moreira Thire received her . degree in
materials and metallurgical engineering (2003) from Federal University
of Rio de Janeiro (UFRJ), Brazil. She is currently a full-time professor
at Program of Metallurgical and Materials Engineering (PEMM), UFRJ,
Brazil, conducting teaching activities to graduate and undergraduate
students and developing researches focused on polymers for
biomedical and technological applications. Her main research interests
are polymeric and composite biomaterials for bone and skin tissue
engineering, drug-loaded biomaterials, additive manufacturing,
electrospinning and biodegradable plastics. She is the head of
Biomaterial area of PEMM/COPPE/UFRJ, leader of the “Technology
in Biomaterials” Research Group, board member of Latin American
Society of Biomaterials and Artificial Organs (SLABO) and a member of
the Brazilian Committee for Special Study of Additive Manufacturing
(ABNT/CEE-261) related to ISO/TC 261Technical Committee. Her work
has been recognized with two important Brazilian sponsorships: CNPq
Researcher of Productivity and FAPERJ Scientist of our State.
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