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allied
academies
Joint Event
February 21-22, 2019 | Paris, France
Microbiology & Applied
Microbiology
2
nd
International Conference on
World Congress on
Wound Care, Tissue Repair
and Regenerative Medicine
&
Journal of Trauma and Critical Care | Volume 3
An improved bio fabrication process to enhance cell survival of cartilage regeneration and functionality
of the osteoarthritic knee when enriched with bone marrow mesenchymal stem cells (MSC)
J M Baena, J L Carrillo
and
J A Marchal
REGEMAT 3D, Spain
T
issue regeneration (TR) is currently one of the most
challenging biotechnology unsolved problems. Tissue
engineering (TE) is a multidisciplinary science that aims at
solving the problems of TR. TE could solve pathologies and
improve the quality of life of billions of people around the world
suffering from tissue damages. New advances in stem cell (SC)
research for the regeneration of tissue injuries have opened
a new promising research field. However, research carried
out nowadays with two-dimensional (2D) cell cultures do not
provide the expected results, as 2D cultures do not mimic the
3D structure of a living tissue. Some of the commonly used
polymers for cartilage regeneration are Poly-lactic acid (PLA)
and its derivates as Poly-L-lactic acid (PLLA), Poly(glycolic acids)
(PGAs) and derivates as Poly(lactic-co-glycolic acids) (PLGAs)
and Poly caprolactone (PCL). All these materials can be printed
using fused deposition modelling (FDM), a process in which
a heated nozzle melt a thermoplastic filament and deposit
it in a surface, drawing the outline and the internal filling of
every layer. All this procedure uses melting temperatures that
decrease viability and cell survival. Research groups around
the world are focusing their efforts in finding low temperature
printing thermoplastics or restricted geometries that avoid the
contact of the thermoplastic and cells at a higher temperature
than the physiologically viable. This has mainly 2 problems;
new biomaterials need a long procedure of clearance
before they can be used in clinical used, and restrictions in
geometries will limit the clinical application of 3D printing in TE.
e:
bd1@regemat3d.comJ Trauma Crit Care, Volume 3
DOI: 10.4066/2591-7358-C1-003