world-biochem-regenerative-medicine-2019-posters-abstracts

Note:

World Biochem 2019 & Regenerative Medicine 2019

Journal of Genetics and Molecular Biology | Volume 3

Page 48

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

March 25-26, 2019 | Amsterdam, Netherlands

BIOCHEMISTRY AND ENZYMOLOGY

World Congress on

TISSUE ENGINEERING AND REGENERATIVE MEDICINE, STEM CELL RESEARCH

Global Conference on

Joint Event on

TISSUE ENGINEERED POLY (VINYL ALCOHOL) MESH FOR THE TREATMENT

OF ABDOMINAL HERNIA

Daniella Feher

and

Kristóf Molnár

Semmelweis University, Hungary

ernia is the weakness or defect in the abdominal wall or inguinal area. One of the solutions can be the usage

of surgical mesh. To fend off the effects of intraperitoneal positioned non-degradable mesh our research

group created absorbable scaffolds by electrospinning. For the biocompatibility experiments

In vitro

studies

were performed on Human lung epithelial (A549) cell line and the

In vivo

evaluations were observed on Wistar

rats (n=45, 200-250g). In this animal model to determine the biological behavior abdominal wall defect was

performed than was covered with the nanofiber mesh. Adhesion formations were measured by a modified Di-

amond score. From the samples macroscopically and histological responses were graded.

In vitro

examination

showed that the monomers of the nanofiber are biocompatible for the cells. According to the histological ex-

aminations all samples were integrated to the surrounding tissue and there were no foreign body reaction. Sig-

nificantly more adhesion formation were found on the non-absorbable suture line (n=19) than were attached to

the surface of the mesh.

The biocompatibility of the nanofiber surgical mesh was demonstrated by our studies. This nanofiber mesh

could be a promising scaffold for the tissue engineering.

Daniella Feher et al., J Genet Mol Biol 2019, Volume 3

Daniella Feher is a PhD student from Semmelweis University, Hungary. Her research is about regenerative medicine

tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating cells,

tissues and nanofibers to restore and establish normal function.

BIOGRAPHY