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Journal of Clinical and Experimental Toxicology | Volume: 2
December 03-04, 2018 | Dubai, UAE
International Conference on
6th International Conference on
Toxicology, Clinical Toxicology & Pharmacology
Recycling & Waste Management
Joint Event
&
Autism: A complete therapeutic approach to ameliorate propionic acid intoxicated mitochondrial
complexes dysfunction: Breakthrough to develop a new diagnostic strategies
Sidharth Mehan
IFS College of Pharmacy, India
Mitochondrial complexes enzymes (I, II, IV & V) dysfunction
increases neuroinflammatory cytokines, oxidative
stress and alterations of brain metabolic enzymes may be
key pathological hallmarks of autism. Propionic acid (PPA),
an endogenous metabolite produced by gut bacteria and
commonly served as food preservative. Here, first time in the
history of this Propionic acid animal model we established
and validate the huge range of behavioural, biochemical,
neuropathological, morphological and histopathological effects
of direct adenyl cyclase activator Forskolin (FSK) in adult rat’s
brain tissue homogenate, serum and urine in comparison
with control drugs used in Autistic patients. Intraventricular
injection of PPA in rats caused impairment in memory, grip
strength posture and cognitive function. Biochemical analysis
of brain homogenate, serum and urine samples in PPA treated
rats showed an increase in altered mitochondrial complexes
activities, inflammatory cytokines, oxidative stress and lipid
biomarkers. Neurohistological and morphological alterations of
hippocampus, basal ganglia and cerebral cortex of PPA treated
rats exhibit severe neuronal space, irregular damaged cells,
dense pyknotic nuclei associated marked focal diffused gliosis.
Forskolin (10, 20 and 30 mg/kg, p.o) once daily treatment for
a period of 15 days significantly improved motor performance
and cognitive behavior task. Further, Forskolin treatment
significantly improved mitochondrial complexes enzyme
activity, attenuated inflammatory and oxidative damage of
rat brain. In present research work, neuroprotective effects of
direct AC activator Forskolin responsible for activation of cAMP/
PKA further leads to CREB activation, and through the repairing
in the basal ganglia, cortex and hippocampus functioning
associate with mitochondrial dysfunctioning in autism as well
as Forskolin effectively reduced the side effects such as weight
gain, gastric discomforts, irritation associatedwith control drugs
used in Autistic patients.
Speaker Biography
Sidharth Mehan is working as Associate Professor in Department of Pharmacology at ISF
College of Pharmacy, Moga, Punjab, India, one of the best well renown and prestigious
Pharma education and research institute in India. He has more than 10 years of academics,
research and administrative experience to his credit and simultaneously working as Doping
ControlOfficeronempanelmentinMinistryofYouthAffairs&Sports,Govt.ofIndia,Delhiand
working online as Senior Clinical Dietitian & Nutritionist consultant in Sanjivani Hospital (A
Super &Multi speciality Hospital), Sirsa, Haryana as well as in other onlinemedical agencies
in India. He has publishedmore than 75 research and review articles in prestigious National
andInternationalJournals.Hisareasofresearchincludemolecularpharmacology,Behavioral
Pharmacology, Neuropharmacology, Sports Sciences and Traditional and Complementary
systems of Medicine. He has so far guided 24 M. Pharm Research projects and 04 Doctoral
Theses. Furthermore, he is associated with Animal welfare activities for last 12 years.
e:
Sidharth Mehan, Toxicology 2018 & Recycling 2018, Volume 2
DOI: 10.4066/2630-4570-C1-002