4 / 4
allied
academies
Page 15
Biomedical Research (An International Journal of Medical Sciences) | ISSN: 0976-1683 Volume 30
June 06-07, 2019 | London, UK
2
nd
International Conference on
Tissue Science and Molecular Biology,
Stem Cells & Separation Techniques
Joint Event
Antonello Petrella
University of Salerno, Italy
Mesoglycan induces keratinocyte differentiation through
syndecan-4 and annexin A1/S100A11 complex: A new drug-induced
side road to stimulate re-epithelialization
W
oundhealingisadynamicprocesscomprisingmultiple
events as inflammation, re-epithelialization and
tissue remodelling. Re-epithelialization phase is characterized
by the engagement of several cell populations, mainly
of keratinocytes that sequentially go through cycles of
migration, proliferation and differentiation to restore skin
functions. Troubles can arise during the re-epithelialization
phase of skin wound healing particularly in keratinocyte
migration, resulting in chronic non-healing lesions which
represent a serious clinical problem. Over the last decades
efforts aimed to find new pharmacological approaches
for wound care were made, yet almost all current
therapeutic strategies employed remain inadequate or
even ineffective. As such, it is crucial to identify new drugs
that can enable a proper regeneration of the epithelium
in a wounded skin. Here, we have investigated the effects
of the fibrinolytic drug mesoglycan, a glycosaminoglycans
mixture derived from porcine intestinal mucosa on
HaCaT human keratinocytes that were used as
in vitro
experimental model of skin re-epithelialization. We found
that mesoglycan induces keratinocyte migration and early
differentiation by triggering syndecan-4/PKCα pathway and
that this effect was at least in part, due to the formation of
the annexin A1/S100A11 complex. Our data suggest that
mesoglycan may be useful as new pro-healing drug for skin
wound care.
Speaker Biography
Antonello Petrella is professor of Pharmacology at University of Salerno-
Department of Pharmacology, Italy. Antonello Petrella has over 60
publications that have been cited over 1300 times and his publication
h-index is 23 and has been serving as an editorial board member of
reputed Journals.
e:
apetrella@unisa.itAntonello Petrella
, Biomed Res, Volume 30
ISSN: 0976-1683