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May 20-21, 2019 | Rome, Italy
Journal of Cell Science and Mutation | Volume 3
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Stem Cell Congress 2019
STEM CELLS AND REGENERATIVE MEDICINE
2nd International Conference on
PROTECTIVE EFFECT OF DANGGUI (RADIX ANGELICAE SINENSIS) WITH RADSCS
CO-TREATMENT INDUCE CARDIAC FUNCTION IN SHR MODEL
Parthasarathi Barik 1, Shibu M A1, T-S Chen2, Wei-Wan Kuo3 and Chih-yang Huang1,4,5,6,7
1 Graduate Institute of Basic Medical Science, China Medical University, Taiwan
2 School of Life Science, National Taiwan Normal University, Taiwan
3 Translation Research Core, China Medical University, Taiwan
4 Department of Biological Science and Technology, China Medical University, Taiwan
5 School of Chinese Medicine, China Medical University, Taiwan
6 Department of Food Nutrition and Health Biotechnology, Asia University, Taiwan
7 Medical Research Center for Exosome and Mitochondria Related Diseases, China Medical University and Hospital,
Taiwan
Hypertension is one of the leading causes of cardiovascular disease associated mortality. At present treat-
ments used to control hypertension and its comorbidities do not exhibit satisfactory effects. Enhancing
stem cell associated recovery function is one of the possible approaches to treat hypertension associated dam-
ages. Several strategies are used to enhance the regenerative benefits of endogenous as well as transplanted
stem cells in treating cardiovascular diseases. In this respect, traditional Chinese medicine which is a primitive
approach in treating various pathological problems attracts convincing interest. Root extract from Danggui
with vasodilatory effects has been used as a traditional Chinese medicine (TCM) to regulate blood flow as well
as to treat myocardial ischemic injury. This study evaluates the effect of Danggui in potentiating and comple-
menting the effects of transplanted rat adipose derived stem cells (rADSCs) to regulate cardiac damages and
to improve cardiac function in spontaneously hypertensive rats (SHR). SHRs with abnormal cardiac contractile
function and apoptosis of the heart cells didn’t show any significant change with tail vein treatment of rADSCs.
However, in SHRs with rADSCs and orally administered Danggui the ejection fraction was reverted to that of the
control and the apoptotic rates were significantly reduced. In vitro analysis also shows that Danggui treatment
enhanced the survival of rADSCs. The novel study first time demonstrates that only stem cell transplantation
in hypertensive condition doesn’t improve cardiac function however, combined treatment of Danggui and
rADSCs induce cell survival as well as improve cardiac function in both in vitro and in vivo model. The previous
report from our lab shows that Danggui induces cell survival in cardiomyocytes. Further to verify in animal
model, we found that combination treatment induces the cardiac function by properly regulating its ejection
fraction and fractional shortening in SHR model, which can be used for regenerative medicine.
Parthasarathi Barik et al., Adv Cell Sci Mut. 2019, Volume 3
Parthasarathi Barik is pursuing his PhD at China Medical University, Taiwan. Earlier, he worked as a project fellow at CSIR Labs, India.
He has published three papers and two more papers in international journals. He also presented few papers in the conferences and
also contributed the research articles to conference proceedings. Currently he is working in rat adipose derived stem cells (rADSCs)
and their therapeutic approach in various pathological problems with traditional Chinese drugs. He is also good in experimental
works in laboratory along with related software exposures. Apart from his scientific credential he is very much active in the aca-
demic capacity building and human resource development where he discussed and helped the college students for the better
understanding of life sciences. He also got a position in Physics Olympiad in national level.
BIOGRAPHY